核小体定位与高阶基因组折叠之间的关系。

IF 6 2区生物学 Q1 CELL BIOLOGY Current Opinion in Cell Biology Pub Date : 2024-07-10 DOI:10.1016/j.ceb.2024.102398

Abrar Aljahani , Clemens Mauksch , A. Marieke Oudelaar

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引用次数: 0

摘要

真核生物基因组由三维结构组成，小到核小体阵列，大到染色质结构域。这些结构在转录和其他核过程的调控中发挥着重要作用。尽管我们对基因组结构的特性、功能和内在机制的认识有所进步，但关于这些结构在不同尺度上的相互作用仍有许多未决问题。特别是，我们还不太清楚核糖体阵列的一维特征是否以及如何影响大规模的三维基因组折叠模式。在这篇综述中，我们将讨论近期针对这些问题开展的研究，并总结我们目前对核糖体定位与高阶基因组折叠之间关系的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The relationship between nucleosome positioning and higher-order genome folding

Eukaryotic genomes are organized into 3D structures, which range from small-scale nucleosome arrays to large-scale chromatin domains. These structures have an important role in the regulation of transcription and other nuclear processes. Despite advances in our understanding of the properties, functions, and underlying mechanisms of genome structures, there are many open questions about the interplay between these structures across scales. In particular, it is not well understood if and how 1D features of nucleosome arrays influence large-scale 3D genome folding patterns. In this review, we discuss recent studies that address these questions and summarize our current understanding of the relationship between nucleosome positioning and higher-order genome folding.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.