败血症研究:异质性是基础而非事后考虑。

IF 11.1 Q1 CELL BIOLOGY Cell genomics Pub Date : 2024-07-10 DOI:10.1016/j.xgen.2024.100608
Timothy H Ciesielski
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引用次数: 0

摘要

脓毒症是一种同质性疾病,这一隐含假设阻碍了我们对脓毒症的了解。在本期的《细胞基因组学》(Cell Genomics)杂志上,Burnham 等人1 已开始描述脓毒症个体反应变异的基因变异和调控网络的特征;这可能最终有助于开发有针对性的干预措施。
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Sepsis research: Heterogeneity as a foundation rather than an afterthought.

Our understanding of sepsis has been hampered by the implicit assumption that sepsis is a homogeneous disease. In this issue of Cell Genomics, Burnham et al.1 have started to characterize the genetic variants and regulatory networks that underlie variations in the individual response to sepsis; this may eventually enable targeted intervention development.

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