Min-Yang Wang, Ying Yu, Yu Han, Yang Yang, Wan Jiang, Jin Liu, Lin-Feng Yan, Guang-Bin Cui
{"title":"传统磁共振成像结合扩散加权成像对微小泌乳素瘤的诊断价值。","authors":"Min-Yang Wang, Ying Yu, Yu Han, Yang Yang, Wan Jiang, Jin Liu, Lin-Feng Yan, Guang-Bin Cui","doi":"10.1002/jmri.29531","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Turbo spin-echo (TSE) diffusion-weighted imaging (DWI) sequences may reduce susceptibility artifacts and image distortion in sellar region, allowing better visualization of small pituitary lesions, and may be used to assist in the diagnosis of pituitary microadenomas.</p><p><strong>Purpose: </strong>To explore the application value of conventional MRI combined with DWI sequences in the diagnosis of microprolactinomas.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>Thirty-four patients in microprolactinomas with high signal on T<sub>2</sub>WI (HT<sub>2</sub>-PRL) group (34 females, 34 ± 7 years), 26 patients in microprolactinomas with equal or low signal on T<sub>2</sub>WI (ELT<sub>2</sub>-PRL) group (21 females, 34 ± 7 years), 35 patients with hyperprolactinemia (33 females, 32 ± 8 years), and 30 normal controls (25 females, 31 ± 7 years).</p><p><strong>Field strength/sequence: </strong>TSE sequence at 3 T.</p><p><strong>Assessment: </strong>Pituitary morphological parameters (such as length and volume), dynamic contrast-enhanced parameters (such as time to peak) and the apparent diffusion coefficients (ADCs) were measured in each group.</p><p><strong>Statistical tests: </strong>ANOVA and Mann-Whitney U test were used to compare parameters among groups. Spearman's coefficient was used to evaluate the correlation between variables. ROC analysis was used to assess the performance of the parameters. A P-value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>The pituitary volume of patients in HT<sub>2</sub>-PRL, ELT<sub>2</sub>-PRL, and hyperprolactinemia group were 831.00 (747.60, 887.60), 923.63 ± 219.34, and 737.20 (606.40, 836.80) mm<sup>3</sup>. The pituitary maximum height in these three groups were 7.03 (6.43, 8.63), 8.03 ± 1.41, and 6.63 ± 1.28 mm, respectively. The lesion ADC value was significantly correlated with T<sub>2</sub> relative signal intensity (the ratio of signal intensity of microprolactinoma or anterior pituitary to left temporal cortex) (r = 0.821). Compared with patients with hyperprolactinemia, the diagnostic efficacy of T<sub>2</sub> relative signal intensity was higher in HT<sub>2</sub>-PRL group, with an AUC of 0.954, whereas the ADC value was the highest in ELT<sub>2</sub>-PRL group, with an AUC of 0.924.</p><p><strong>Conclusion: </strong>DWI sequences can be used to assist in the diagnosis of pituitary microadenomas.</p><p><strong>Evidence level: </strong>1 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Diagnostic Value of Conventional MRI Combined With Diffusion-Weighted Imaging in Microprolactinomas.\",\"authors\":\"Min-Yang Wang, Ying Yu, Yu Han, Yang Yang, Wan Jiang, Jin Liu, Lin-Feng Yan, Guang-Bin Cui\",\"doi\":\"10.1002/jmri.29531\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Turbo spin-echo (TSE) diffusion-weighted imaging (DWI) sequences may reduce susceptibility artifacts and image distortion in sellar region, allowing better visualization of small pituitary lesions, and may be used to assist in the diagnosis of pituitary microadenomas.</p><p><strong>Purpose: </strong>To explore the application value of conventional MRI combined with DWI sequences in the diagnosis of microprolactinomas.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>Thirty-four patients in microprolactinomas with high signal on T<sub>2</sub>WI (HT<sub>2</sub>-PRL) group (34 females, 34 ± 7 years), 26 patients in microprolactinomas with equal or low signal on T<sub>2</sub>WI (ELT<sub>2</sub>-PRL) group (21 females, 34 ± 7 years), 35 patients with hyperprolactinemia (33 females, 32 ± 8 years), and 30 normal controls (25 females, 31 ± 7 years).</p><p><strong>Field strength/sequence: </strong>TSE sequence at 3 T.</p><p><strong>Assessment: </strong>Pituitary morphological parameters (such as length and volume), dynamic contrast-enhanced parameters (such as time to peak) and the apparent diffusion coefficients (ADCs) were measured in each group.</p><p><strong>Statistical tests: </strong>ANOVA and Mann-Whitney U test were used to compare parameters among groups. Spearman's coefficient was used to evaluate the correlation between variables. ROC analysis was used to assess the performance of the parameters. A P-value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>The pituitary volume of patients in HT<sub>2</sub>-PRL, ELT<sub>2</sub>-PRL, and hyperprolactinemia group were 831.00 (747.60, 887.60), 923.63 ± 219.34, and 737.20 (606.40, 836.80) mm<sup>3</sup>. The pituitary maximum height in these three groups were 7.03 (6.43, 8.63), 8.03 ± 1.41, and 6.63 ± 1.28 mm, respectively. The lesion ADC value was significantly correlated with T<sub>2</sub> relative signal intensity (the ratio of signal intensity of microprolactinoma or anterior pituitary to left temporal cortex) (r = 0.821). Compared with patients with hyperprolactinemia, the diagnostic efficacy of T<sub>2</sub> relative signal intensity was higher in HT<sub>2</sub>-PRL group, with an AUC of 0.954, whereas the ADC value was the highest in ELT<sub>2</sub>-PRL group, with an AUC of 0.924.</p><p><strong>Conclusion: </strong>DWI sequences can be used to assist in the diagnosis of pituitary microadenomas.</p><p><strong>Evidence level: </strong>1 TECHNICAL EFFICACY: Stage 2.</p>\",\"PeriodicalId\":16140,\"journal\":{\"name\":\"Journal of Magnetic Resonance Imaging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Magnetic Resonance Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jmri.29531\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Magnetic Resonance Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jmri.29531","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
The Diagnostic Value of Conventional MRI Combined With Diffusion-Weighted Imaging in Microprolactinomas.
Background: Turbo spin-echo (TSE) diffusion-weighted imaging (DWI) sequences may reduce susceptibility artifacts and image distortion in sellar region, allowing better visualization of small pituitary lesions, and may be used to assist in the diagnosis of pituitary microadenomas.
Purpose: To explore the application value of conventional MRI combined with DWI sequences in the diagnosis of microprolactinomas.
Study type: Prospective.
Population: Thirty-four patients in microprolactinomas with high signal on T2WI (HT2-PRL) group (34 females, 34 ± 7 years), 26 patients in microprolactinomas with equal or low signal on T2WI (ELT2-PRL) group (21 females, 34 ± 7 years), 35 patients with hyperprolactinemia (33 females, 32 ± 8 years), and 30 normal controls (25 females, 31 ± 7 years).
Field strength/sequence: TSE sequence at 3 T.
Assessment: Pituitary morphological parameters (such as length and volume), dynamic contrast-enhanced parameters (such as time to peak) and the apparent diffusion coefficients (ADCs) were measured in each group.
Statistical tests: ANOVA and Mann-Whitney U test were used to compare parameters among groups. Spearman's coefficient was used to evaluate the correlation between variables. ROC analysis was used to assess the performance of the parameters. A P-value <0.05 was considered statistically significant.
Results: The pituitary volume of patients in HT2-PRL, ELT2-PRL, and hyperprolactinemia group were 831.00 (747.60, 887.60), 923.63 ± 219.34, and 737.20 (606.40, 836.80) mm3. The pituitary maximum height in these three groups were 7.03 (6.43, 8.63), 8.03 ± 1.41, and 6.63 ± 1.28 mm, respectively. The lesion ADC value was significantly correlated with T2 relative signal intensity (the ratio of signal intensity of microprolactinoma or anterior pituitary to left temporal cortex) (r = 0.821). Compared with patients with hyperprolactinemia, the diagnostic efficacy of T2 relative signal intensity was higher in HT2-PRL group, with an AUC of 0.954, whereas the ADC value was the highest in ELT2-PRL group, with an AUC of 0.924.
Conclusion: DWI sequences can be used to assist in the diagnosis of pituitary microadenomas.
期刊介绍：
The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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