Ao-Xue Ding , Yi-Ming Shan , Chen-Yue Li , Guo-Qing Qin , Tong Chen , Qing Wang , Xiang-Gang Hu , Peng-Ju Guo , Hai-Jun Yu , Wen-Qiong Wang , Li-Jiang Xuan
{"title":"具有铁中毒诱导活性的 Tithonia diversifolia 中的倍半萜内酯。","authors":"Ao-Xue Ding , Yi-Ming Shan , Chen-Yue Li , Guo-Qing Qin , Tong Chen , Qing Wang , Xiang-Gang Hu , Peng-Ju Guo , Hai-Jun Yu , Wen-Qiong Wang , Li-Jiang Xuan","doi":"10.1016/j.phytochem.2024.114219","DOIUrl":null,"url":null,"abstract":"<div><p>Eight previously undescribed sesquiterpene lactones (<strong>1</strong>–<strong>8</strong>), together with six known ones (<strong>9</strong>–<strong>14</strong>) were isolated from the aerial parts of <em>Tithonia diversifolia</em> (Hemsl.) A. Gray. The absolute configurations of these compounds were elucidated using HRMS, NMR spectroscopy, optical rotation measurements, X-ray crystallography, and ECD. Among them, sesquiterpene lactones <strong>2</strong>–<strong>4</strong> share a unique carbon skeleton with a rare C-3/C-4 ring-opened structure. Compounds <strong>1</strong> and <strong>8</strong> showed moderate inhibitory effects toward CT26 murine colon carcinoma cells by promoting lipid ROS production, highlighting their potential as ferroptosis inducers.</p></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sesquiterpene lactones from Tithonia diversifolia with ferroptosis-inducing activities\",\"authors\":\"Ao-Xue Ding , Yi-Ming Shan , Chen-Yue Li , Guo-Qing Qin , Tong Chen , Qing Wang , Xiang-Gang Hu , Peng-Ju Guo , Hai-Jun Yu , Wen-Qiong Wang , Li-Jiang Xuan\",\"doi\":\"10.1016/j.phytochem.2024.114219\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Eight previously undescribed sesquiterpene lactones (<strong>1</strong>–<strong>8</strong>), together with six known ones (<strong>9</strong>–<strong>14</strong>) were isolated from the aerial parts of <em>Tithonia diversifolia</em> (Hemsl.) A. Gray. The absolute configurations of these compounds were elucidated using HRMS, NMR spectroscopy, optical rotation measurements, X-ray crystallography, and ECD. Among them, sesquiterpene lactones <strong>2</strong>–<strong>4</strong> share a unique carbon skeleton with a rare C-3/C-4 ring-opened structure. Compounds <strong>1</strong> and <strong>8</strong> showed moderate inhibitory effects toward CT26 murine colon carcinoma cells by promoting lipid ROS production, highlighting their potential as ferroptosis inducers.</p></div>\",\"PeriodicalId\":20170,\"journal\":{\"name\":\"Phytochemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031942224002565\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942224002565","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Sesquiterpene lactones from Tithonia diversifolia with ferroptosis-inducing activities
Eight previously undescribed sesquiterpene lactones (1–8), together with six known ones (9–14) were isolated from the aerial parts of Tithonia diversifolia (Hemsl.) A. Gray. The absolute configurations of these compounds were elucidated using HRMS, NMR spectroscopy, optical rotation measurements, X-ray crystallography, and ECD. Among them, sesquiterpene lactones 2–4 share a unique carbon skeleton with a rare C-3/C-4 ring-opened structure. Compounds 1 and 8 showed moderate inhibitory effects toward CT26 murine colon carcinoma cells by promoting lipid ROS production, highlighting their potential as ferroptosis inducers.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
