无细胞 DNA：传染性疾病中一种前景广阔的生物标记物。

IF 14 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Microbiology Pub Date : 2024-07-11 DOI:10.1016/j.tim.2024.06.005

Yuxuan Hu, Yanping Zhao, Yan Zhang, Weijun Chen, Haiqiang Zhang, Xin Jin

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引用次数: 0

摘要

传染病对全球公共卫生构成严重威胁。传统的传染病诊断方法往往灵敏度低、侵入性大、周转时间长。传染病的早期诊断、治疗监测和预后预测迫切需要方便用户的床旁检测。无细胞 DNA（cfDNA）是一种前景广阔的非侵入性生物标记物，被广泛应用于肿瘤学和妊娠学领域，在传染病诊断的临床应用中也显示出巨大的潜力。在此，我们将从病原体和宿主的角度讨论有关传染性疾病的最新 cfDNA 研究。我们还讨论了这一领域的技术挑战，并提出了克服这些挑战的解决方案。此外，我们还对 cfDNA 作为传染病诊断、治疗和预后标志物的潜力进行了展望。

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Cell-free DNA: a promising biomarker in infectious diseases.

Infectious diseases pose serious threats to public health worldwide. Conventional diagnostic methods for infectious diseases often exhibit low sensitivity, invasiveness, and long turnaround times. User-friendly point-of-care tests are urgently needed for early diagnosis, treatment monitoring, and prognostic prediction of infectious diseases. Cell-free DNA (cfDNA), a promising non-invasive biomarker widely used in oncology and pregnancy, has shown great potential in clinical applications for diagnosing infectious diseases. Here, we discuss the most recent cfDNA research on infectious diseases from both the pathogen and host perspectives. We also discuss the technical challenges in this field and propose solutions to overcome them. Additionally, we provide an outlook on the potential of cfDNA as a diagnostic, treatment, and prognostic marker for infectious diseases.

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.