病毒战争一瞥:解码高致病性冠状病毒蛋白在细胞凋亡调控中的奇妙作用。

IF 9 2区 医学 Q1 CELL BIOLOGY Journal of Biomedical Science Pub Date : 2024-07-13 DOI:10.1186/s12929-024-01062-1
Leyi Cheng, Yajuan Rui, Yanpu Wang, Shiqi Chen, Jiaming Su, Xiao-Fang Yu
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引用次数: 0

摘要

冠状病毒采用各种生存策略,其中最突出的是激活内源性或外源性细胞凋亡,而病毒蛋白在其中发挥着关键作用。值得注意的是,与低致病性毒株相比,高致病性冠状病毒(如 SARS-CoV-2、SARS-CoV 和 MERS-CoV)表现出更多的非结构蛋白,从而提高了它们通过多种途径诱导细胞凋亡的能力。此外,这些病毒蛋白善于抑制宿主的免疫反应,从而促进病毒的复制和持续存在。本综述深入探讨了高致病性冠状病毒与细胞凋亡之间错综复杂的相互作用,系统地阐明了病毒蛋白诱导细胞凋亡的分子机制。此外,文章还探讨了将抑制细胞凋亡作为抗病毒药物和利用诱导细胞凋亡的病毒蛋白作为治疗方法的潜在治疗途径。这些见解不仅揭示了病毒的致病机理,还为癌症治疗提供了新的视角。
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A glimpse into viral warfare: decoding the intriguing role of highly pathogenic coronavirus proteins in apoptosis regulation.

Coronaviruses employ various strategies for survival, among which the activation of endogenous or exogenous apoptosis stands out, with viral proteins playing a pivotal role. Notably, highly pathogenic coronaviruses such as SARS-CoV-2, SARS-CoV, and MERS-CoV exhibit a greater array of non-structural proteins compared to low-pathogenic strains, facilitating their ability to induce apoptosis via multiple pathways. Moreover, these viral proteins are adept at dampening host immune responses, thereby bolstering viral replication and persistence. This review delves into the intricate interplay between highly pathogenic coronaviruses and apoptosis, systematically elucidating the molecular mechanisms underpinning apoptosis induction by viral proteins. Furthermore, it explores the potential therapeutic avenues stemming from apoptosis inhibition as antiviral agents and the utilization of apoptosis-inducing viral proteins as therapeutic modalities. These insights not only shed light on viral pathogenesis but also offer novel perspectives for cancer therapy.

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来源期刊
Journal of Biomedical Science
Journal of Biomedical Science 医学-医学:研究与实验
CiteScore
18.50
自引率
0.90%
发文量
95
审稿时长
1 months
期刊介绍: The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.
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