Min Li , Zhen Xia , Lixing Tang , Bensong Zhang , Fupeng Yan , Yukun Jiao , Shiqi Xiang , Shiyu Zhang , Ze Tan , Lin Yu
{"title":"通过钴(III)催化的苯亚甲基酸盐与锍酰化物的 CH酰甲基化/环化反应,以氧化还原中性方式获得异喹啉类化合物","authors":"Min Li , Zhen Xia , Lixing Tang , Bensong Zhang , Fupeng Yan , Yukun Jiao , Shiqi Xiang , Shiyu Zhang , Ze Tan , Lin Yu","doi":"10.1016/j.tetlet.2024.155185","DOIUrl":null,"url":null,"abstract":"<div><p>A practical and highly efficient method for the regioselective synthesis of isoquinolines was developed via cobalt-catalyzed C(sp<sup>2</sup>)−H activation and subsequent intramolecular tandem annulations between benzimidates and sulfoxonium ylides. Key to the success of this transformation was the use of an inexpensive and bench-stable Cp*Co(III)-catalyst. Various functionalized isoquinolines were prepared successfully under base-free and oxidant-free conditions. This protocol features simple operation, broad substrate scope, and good functional group tolerance. Moreover, the reaction is scalable and tolerant of ambient air and moisture.</p></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Redox-neutral access to isoquinolines via cobalt(III)-catalyzed CH acylmethylation/cyclization of benzimidates with sulfoxonium ylides\",\"authors\":\"Min Li , Zhen Xia , Lixing Tang , Bensong Zhang , Fupeng Yan , Yukun Jiao , Shiqi Xiang , Shiyu Zhang , Ze Tan , Lin Yu\",\"doi\":\"10.1016/j.tetlet.2024.155185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A practical and highly efficient method for the regioselective synthesis of isoquinolines was developed via cobalt-catalyzed C(sp<sup>2</sup>)−H activation and subsequent intramolecular tandem annulations between benzimidates and sulfoxonium ylides. Key to the success of this transformation was the use of an inexpensive and bench-stable Cp*Co(III)-catalyst. Various functionalized isoquinolines were prepared successfully under base-free and oxidant-free conditions. This protocol features simple operation, broad substrate scope, and good functional group tolerance. Moreover, the reaction is scalable and tolerant of ambient air and moisture.</p></div>\",\"PeriodicalId\":438,\"journal\":{\"name\":\"Tetrahedron Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-07-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040403924002806\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924002806","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Redox-neutral access to isoquinolines via cobalt(III)-catalyzed CH acylmethylation/cyclization of benzimidates with sulfoxonium ylides
A practical and highly efficient method for the regioselective synthesis of isoquinolines was developed via cobalt-catalyzed C(sp2)−H activation and subsequent intramolecular tandem annulations between benzimidates and sulfoxonium ylides. Key to the success of this transformation was the use of an inexpensive and bench-stable Cp*Co(III)-catalyst. Various functionalized isoquinolines were prepared successfully under base-free and oxidant-free conditions. This protocol features simple operation, broad substrate scope, and good functional group tolerance. Moreover, the reaction is scalable and tolerant of ambient air and moisture.
期刊介绍:
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.