Efferocytosis:揭示其在自身免疫性疾病和治疗策略中的潜力

IF 9.2 1区 医学 Q1 IMMUNOLOGY Autoimmunity reviews Pub Date : 2024-06-01 DOI:10.1016/j.autrev.2024.103578
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引用次数: 0

摘要

吞噬作用是吞噬细胞吞噬和消除凋亡细胞(AC)的关键过程。这一复杂的过程可分为四个步骤:(1) ACs 释放 "找到我 "的信号以吸引吞噬细胞;(2) ACs 发出 "吃掉我 "的信号引导吞噬作用;(3) 吞噬细胞吞噬并内化 ACs;(4) ACs 降解。维持免疫平衡在很大程度上依赖于 ACs 的有效清除,因为 ACs 清除了自身抗原,促进了抗炎和免疫抑制信号的产生,从而维持了免疫耐受。然而,在细胞凋亡过程中,任何一个排出步骤发生中断都会导致清除凋亡细胞的效率降低。导致这种效率低下的因素包括 "找到我 "或 "吃掉我 "信号的释放和识别失调、吞噬细胞表面受体、桥接分子和其他信号通路的缺陷。AC 清除不足会导致其破裂并随之释放自身抗原,从而促进免疫反应并诱发自身免疫性疾病,如系统性红斑狼疮、类风湿性关节炎、1 型糖尿病和多发性硬化症。全面了解渗出过程及其影响可为开发针对这一过程的新型治疗策略提供宝贵的见解,从而预防或治疗自身免疫性疾病。
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Efferocytosis: Unveiling its potential in autoimmune disease and treatment strategies

Efferocytosis is a crucial process whereby phagocytes engulf and eliminate apoptotic cells (ACs). This intricate process can be categorized into four steps: (1) ACs release “find me” signals to attract phagocytes, (2) phagocytosis is directed by “eat me” signals emitted by ACs, (3) phagocytes engulf and internalize ACs, and (4) degradation of ACs occurs. Maintaining immune homeostasis heavily relies on the efficient clearance of ACs, which eliminates self-antigens and facilitates the generation of anti-inflammatory and immunosuppressive signals that maintain immune tolerance. However, any disruptions occurring at any of the efferocytosis steps during apoptosis can lead to a diminished efficacy in removing apoptotic cells. Factors contributing to this inefficiency encompass dysregulation in the release and recognition of “find me” or “eat me” signals, defects in phagocyte surface receptors, bridging molecules, and other signaling pathways. The inadequate clearance of ACs can result in their rupture and subsequent release of self-antigens, thereby promoting immune responses and precipitating the onset of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, and multiple sclerosis. A comprehensive understanding of the efferocytosis process and its implications can provide valuable insights for developing novel therapeutic strategies that target this process to prevent or treat autoimmune diseases.

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来源期刊
Autoimmunity reviews
Autoimmunity reviews 医学-免疫学
CiteScore
24.70
自引率
4.40%
发文量
164
审稿时长
21 days
期刊介绍: Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.
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