黑人和白人炎症性肠病患者的黏膜愈合情况。

IF 3 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Clinical and Translational Gastroenterology Pub Date : 2024-08-01 DOI:10.14309/ctg.0000000000000737
Devika Dixit, Nicole C Ruiz, Steve Shen, Arvin Daneshmand, Vanessa I Rodriguez, Steve Qian, Dan Neal, S Devi Rampertab, Ellen M Zimmermann, Amir Y Kamel
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引用次数: 0

摘要

简介克罗恩病(CD)和溃疡性结肠炎(UC)以胃肠道慢性炎症为特征。黏膜愈合(MH)是 IBD 患者的治疗目标。目前的数据表明,黑人 IBD 患者的临床疗效可能不如白人患者。本研究对黑人和白人 IBD 患者的黏膜愈合情况进行了评估:方法:对因病情发作住院的黑人和白人成年 IBD 患者进行回顾性分析。入院后 6-18 个月时对是否存在 MH 进行了评估。记录了住院前、住院期间、住院6个月内和出院后6-18个月内接受的IBD治疗。收集住院时和出院后 6-18 个月的 C 反应蛋白(CRP)水平;差异以 delta CRP 报告:结果:109 名患者在住院后接受了随访。其中 88 人(80.7%)为白人患者,21 人(19.3%)为黑人患者。白人和黑人患者在住院前(p=0.2)、住院期间(p=0.6)、出院后 6 个月内(p=0.1)和 6-18 个月内(p=0.1)接受 IBD 治疗的比例相似。黑人患者的 MH(15/21=71.4% vs. 53/88=60.2%,p=0.3)和 delta CRP(p=0.2)率均高于白人患者,但无统计学意义:结论:在接受类似治疗和护理的 IBD 复发入院患者中,黑人患者的 MH 发生率有高于白人患者的趋势。这些数据表明,与白人患者相比,MH 可能不是导致黑人患者临床治疗效果较差的唯一因素。
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Mucosal Healing Among Black and White Patients With Inflammatory Bowel Disease.

Introduction: Crohn's disease and ulcerative colitis are characterized by chronic inflammation of the gastrointestinal tract. Mucosal healing (MH) is a therapeutic goal in patients with inflammatory bowel disease (IBD). Current data suggest that Black patients may experience worse clinical outcomes than White patients with IBD. This study assessed MH between Black and White patients with IBD.

Methods: Retrospective analysis was performed on Black and White adults with IBD who were hospitalized for an active flare. The presence of MH was assessed at 6-18 months after hospitalization. IBD treatments received before and during hospitalization, within 6 months, and 6-18 months after discharge were recorded. C-reactive protein (CRP) levels were collected at hospitalization and 6-18 months after discharge; the difference was reported as delta CRP.

Results: One hundred nine patients were followed up after hospitalization. Of those 88 (80.7%) were White patients, and 21 (19.3%) were Black patients. White and Black patients received similar proportions of IBD treatment before ( P = 0.2) and during ( P = 0.6) hospitalization, within 6 months ( P = 0.1), and 6-18 months ( P = 0.1) after discharge. Black patients achieved numerically higher rates of MH (15/21 = 71.4% vs 53/88 = 60.2%, P = 0.3) and delta CRP ( P = 0.2) than White patients, however, not statistically significant.

Discussion: In patients admitted to the hospital with an IBD flare with similar treatment and care, there was a trend toward higher rates of MH in Black patients compared with White patients. These data suggest that MH is likely not the only factor that is associated with Black patients experiencing worse clinical outcomes when compared with White patients.

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来源期刊
Clinical and Translational Gastroenterology
Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
7.00
自引率
0.00%
发文量
114
审稿时长
16 weeks
期刊介绍: Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.
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