在两个样本中,习惯性使用咖啡因与皮质醇对实验室压力的反应性增强有关。

IF 2.9 3区 医学 Q2 PSYCHIATRY Psychosomatic Medicine Pub Date : 2024-10-01 Epub Date: 2024-07-15 DOI:10.1097/PSY.0000000000001334
Elli L Cole, Alessandra R Grillo, Suzanne Vrshek-Schallhorn
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引用次数: 0

摘要

目的:习惯性饮用咖啡因可预防抑郁症,但其机制尚不清楚。虽然习惯性摄入咖啡因可预测皮质醇在其他急性应激源(如运动)下的释放,但在健康成年人中,这一点在实验室社会心理应激中的研究较少。此外,咖啡因诱导的皮质醇增加可能会掩盖理论预测的皮质醇对抑郁风险升高的人的强大压力的钝化作用。在两个样本中,我们测试了急性(当天)和习惯性使用咖啡因是否会预测皮质醇对实验室压力的反应性,以及咖啡因是否会 "掩盖 "抑郁风险因素特质反刍对皮质醇反应性减弱的影响:在样本 1 中,N = 128 名新成人完成了三种特里尔社会压力测试条件之一:非评价性控制、模糊评价性中间或明确的负面评价。在样本 2 中,N=148 名新成人完成了 "控制 "或 "消极评价 "条件之一:在这两个样本中,多层次生长曲线建模显示,习惯性(t = -1.99, p = .048; t = -2.73, p = .007,分别为样本 1 和样本 2)而非急性咖啡因使用可预测皮质醇反应性的升高。在样本 1 中,条件、反刍和皮质醇钝化之间的关系仅在非咖啡因使用者中明显,这与使用者不同(t = 2.82,p = .005),但在样本 2 中,无论是否使用咖啡因,预测的钝化模式都很明显:这提供了证据,证明习惯性使用咖啡因与心理社会实验室压力下皮质醇的更大释放有关,并可能掩盖心理社会变量的影响;未来的研究应探讨习惯性使用咖啡因引起的皮质醇释放是否具有行为激活效应,从而保护人们免受抑郁的影响。
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Habitual Caffeine Use Is Associated With Heightened Cortisol Reactivity to Lab-Based Stress in Two Samples.

Objective: Habitual caffeine consumption protects against depression but through unclear mechanisms. Although habitual caffeine use predicts cortisol release in response to other acute stressors (e.g., exercise), this is less examined with lab-based psychosocial stress in healthy adults. Furthermore, caffeine-induced cortisol increases may mask theory-predicted cortisol blunting to robust stress in people with elevated depression risk. In two samples, we tested whether acute (same-day) and habitual caffeine use would predict greater cortisol reactivity to lab-based stress, and whether caffeine would "mask" the effect of a depression risk factor, trait rumination, on blunted cortisol reactivity.

Method: In sample 1, N = 128 emerging adults completed one of three Trier Social Stress Test conditions: nonevaluative control, ambiguously evaluative intermediate, or explicit negative evaluative. In sample 2, N = 148 emerging adults completed either a control or negative evaluative condition.

Results: In both samples, multilevel growth curve modeling indicated that habitual caffeine use ( t = -1.99, p = .048; t = -2.73, p = .007, samples 1 and 2, respectively) but not acute caffeine use predicted heightened cortisol reactivity as a function of condition. In sample 1, the relationship between condition, rumination, and blunted cortisol was evident only in caffeine nonusers, which differed from users ( t = 2.82, p = .005), but in sample 2, the predicted blunting pattern was evident regardless of caffeine use.

Conclusion: The results provide evidence that habitual caffeine use is associated with greater cortisol release under psychosocial lab-based stress and may mask the influence of psychosocial variables; future research should examine whether habitual caffeine-induced cortisol release has behaviorally activating effects that protect against depression.

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来源期刊
Psychosomatic Medicine
Psychosomatic Medicine 医学-精神病学
CiteScore
5.10
自引率
0.00%
发文量
258
审稿时长
4-8 weeks
期刊介绍: Psychosomatic Medicine is the official peer-reviewed journal of the American Psychosomatic Society. The journal publishes experimental, clinical, and epidemiological studies on the role of psychological and social factors in the biological and behavioral processes relevant to health and disease. Psychosomatic Medicine is an interdisciplinary peer-reviewed journal devoted to high-quality science on biobehavioral mechanisms, brain-behavior interactions relevant to physical and mental disorders, as well as interventions in clinical and public health settings. Psychosomatic Medicine was founded in 1939 and publishes interdisciplinary research articles relevant to medicine, psychiatry, psychology, and other health-related disciplines. The print journal is published nine times a year; most articles are published online ahead of print. Supplementary issues may contain reports of conferences at which original research was presented in areas relevant to the psychosomatic and behavioral medicine.
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