比较三种化疗方案与电化学疗法治疗猫皮肤鳞状细胞癌的效果

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary and comparative oncology Pub Date : 2024-09-01 Epub Date: 2024-07-15 DOI:10.1111/vco.12995
Nicolas Diop, David Sayag, Grégoire Bernardo Marques, Gabriel Chamel, Thomas Chavalle, Jean-Bapiste Eon, Franck Floch, Mathilde Lajoinie, Frédérique Ponce, Laura E Barrett
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引用次数: 0

摘要

使用静脉注射博莱霉素和/或瘤内注射博莱霉素的电化学疗法(ECT)在治疗不可切除的猫皮肤鳞状细胞癌(cSCC)方面疗效显著,反应率高达95%,但尚未对其他化疗方案进行研究。这项前瞻性多中心研究的目的是比较使用IT和静脉注射卡铂(静脉注射+IT)、静脉注射卡铂(静脉注射)或静脉注射博莱霉素(静脉注射)进行ECT治疗的猫皮肤鳞状细胞癌患者的总反应率(ORR)和无进展间隔时间(PFI)。三个中心共招募了44只无法切除的cSCC猫,并使用卡铂静脉注射+IT(10只)、卡铂静脉注射(11只)或博来霉素静脉注射(23只)进行ECT治疗。根据RECIST标准,在治疗后2周和4周记录治疗反应,并随访患者直至疾病进展和/或死亡。三组患者的年龄、性别、体重和病灶大小相当。三组患者的不良反应一般都比较轻微、局部,且组间情况相似。ORR分别为90.0%(卡铂静脉注射+IT)、90.9%(卡铂静脉注射)和95.6%(博莱霉素静脉注射),无显著差异(p = 0.79)。卡铂静脉注射 + IT 或卡铂静脉注射未达到中位 PFI,博莱霉素静脉注射的中位 PFI 为 566 天,三组之间无显著差异(p = 0.81)。这项研究表明,使用静脉注射或静脉注射+IT卡铂的ECT是治疗cSCC的一种合理的替代疗法,有必要进一步研究比较不同治疗方案的疗效。
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Comparison of Three Chemotherapy Protocols With Electrochemotherapy for the Treatment of Feline Cutaneous Squamous Cell Carcinoma.

Electrochemotherapy (ECT) with intravenous (IV) and/or intratumoral (IT) bleomycin has shown considerable efficacy in the treatment of non-resectable feline cutaneous squamous cell carcinoma (cSCC), boasting response rates of up to 95%, but other chemotherapy protocols have not yet been investigated. The objective of this prospective multicentre study was to compare the overall response rate (ORR) and progression-free interval (PFI) between cats with cSCC treated with ECT using IT and IV carboplatin (IV + IT), IV carboplatin (IV) or IV bleomycin (IV). A total of 44 cats with unresectable cSCC across three centres were enrolled and treated with ECT using carboplatin IV + IT (n = 10), carboplatin IV (n = 11) or bleomycin IV (n = 23). Treatment response according to RECIST criteria was recorded at 2 and 4 weeks post-treatment, and patients were followed until disease progression and/or death. All three groups were comparable regarding age, sex, weight, and lesion size. Adverse events were generally mild, localised and similar between groups. ORRs were 90.0% (carboplatin IV + IT), 90.9% (carboplatin IV) and 95.6% (bleomycin IV) and were not significantly different (p = 0.79). Median PFI was not reached for carboplatin IV + IT or carboplatin IV and was 566 days for bleomycin IV, with no significant difference between the three groups (p = 0.81). This study suggests that ECT using IV or IV + IT carboplatin is a reasonable alternative therapeutic option for managing cSCC, and further studies are warranted to compare outcomes between treatment protocols.

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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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