玫瑰红介导的抗菌光动力疗法作为洗牙和根面平整术的辅助疗法对治疗慢性牙周炎的临床和微生物参数的疗效:单盲随机对照临床试验》。

IF 1.8 Q2 SURGERY Photobiomodulation, photomedicine, and laser surgery Pub Date : 2024-08-01 Epub Date: 2024-07-15 DOI:10.1089/pho.2024.0037
Nivedha Nedumaran, Arvina Rajasekar
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引用次数: 0

摘要

研究目的本研究旨在评估以玫瑰红(RB)为介导的抗菌光动力疗法(a-PDT)作为洗牙和根面平整术的辅助手段,在治疗慢性牙周炎患者时的临床参数(如牙龈指数(GI)、探针探入袋深度(PPD)、临床附着水平(CAL))和微生物参数(如总微生物计数、总红色复合菌计数、牙龈卟啉单胞菌计数)方面的疗效、临床参数,如牙龈指数(GI)、探诊袋深度(PPD)、临床附着水平(CAL),以及微生物参数,如微生物总数、红色复合菌总数、牙龈卟啉单胞菌计数、牙髓震颤素计数和连翘菌计数。材料和方法:在这项随机对照临床试验中,共招募了 30 名符合纳入标准的患者。参与者被随机分配到单纯洗牙和根面规划(SRP)的 A 组和 SRP + a-PDT 的 B 组。在基线和 3 个月随访时测量临床和微生物参数。组间和组内比较分别采用独立 t 检验和配对 t 检验。P<0.05为差异有统计学意义。结果:在 3 个月的随访中,接受 SRP + a-PDT 治疗的 B 组的 GI(0.58 ± 0.20)和 PPD(1.81 ± 0.32 mm)显著减少,CAL(0.73 ± 0.04 mm)增加,微生物总数减少 [2.80 ± 0.08 × 104 菌落总数 (CFU)]、红色复合菌总数 (0.29 ± 0.14 × 102 CFU)、牙龈脓疱菌计数 (0.43 ± 0.13 × 102 CFU)、牙菌斑计数 (0.61 ± 0.04 × 102 CFU) 和连翘计数 (0.59 ± 0.04 × 102 CFU) 与 A 组相比均有所减少(P < 0.05)。结论在治疗慢性牙周炎时,RB 介导的 a-PDT 作为 SRP 的辅助治疗与单独使用 SRP 相比,在改善 GI、PPD 和 CAL 以及减少微生物数量方面效果更明显。
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Efficacy of Rose Bengal-Mediated Antimicrobial Photodynamic Therapy as an Adjunct to Scaling and Root Planing on Clinical and Microbiological Parameters in the Management of Chronic Periodontitis: A Single-Blinded, Randomized Controlled Clinical Trial.

Aim: The study aims to assess the efficacy of rose bengal (RB)-mediated antimicrobial photodynamic therapy (a-PDT) as an adjunct to scaling and root planing in the management of chronic periodontitis patients in terms of clinical parameters like gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), and microbiological parameters like total microbial count, total red complex organism count, Porphyromonas gingivalis count, Treponema denticola count, and Tannerella forsythia count. Materials and Methods: In this randomized controlled clinical trial, a total of 30 patients were recruited who met the inclusion criteria. The participants were randomly allocated into group A with scaling and root planning (SRP) alone and group B with SRP + a-PDT. The clinical and microbiological parameters were measured at baseline and at 3-month follow-up. Intergroup and intragroup comparisons were performed using independent t test and paired t test, respectively. Value of p < 0.05 was considered as statistically significant. Results: At 3-month follow-up, group B treated with SRP + a-PDT showed statistically significant reduction in GI (0.58 ± 0.20) and PPD (1.81 ± 0.32 mm), gain in CAL (0.73 ± 0.04 mm), and reduction in total microbial count [2.80 ± 0.08 × 104 colony forming unit (CFU)], total red complex count (0.29 ± 0.14 × 102 CFU), P. gingivalis count (0.43 ± 0.13 × 102 CFU), T. denticola count (0.61 ± 0.04 × 102 CFU), and T. forsythia count (0.59 ± 0.04 × 102 CFU) as compared with group A (p < 0.05). Conclusion: RB-mediated a-PDT as an adjunct to SRP was significantly more effective in improving GI, PPD, and CAL and in reducing microbial count as compared with SRP alone in the management of chronic periodontitis.

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期刊介绍: Photobiomodulation, Photomedicine, and Laser Surgery Editor-in-Chief: Michael R Hamblin, PhD Co-Editor-in-Chief: Heidi Abrahamse, PhD
期刊最新文献
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