2-Azabicyclo[2.2.1]Hept-5-En-3-One (Vince Lactam) 在有机合成和药物化学中的应用。

IF 7 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chemical record Pub Date : 2024-07-15 DOI:10.1002/tcr.202400070

Dr. Melinda Nonn, Prof. Santos Fustero, Prof. Loránd Kiss

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引用次数: 0

摘要

众所周知，2-氮杂双环[2.2.1]庚-5-烯-3-酮（文氏内酰胺）是合成有机化学和药物研究中的重要构件。它是获得某些抗病毒大片药物（如 Carbovir 或 Abacavir）以及其他碳环神经氨酸酶抑制剂作为抗病毒药物的重要前体。文氏内酰胺的环 C=C 键允许进行多种化学操作，不仅可以制造功能化的 γ-内酰胺，还可以制造具有环戊烷框架的 γ-氨基酸衍生物。本报告旨在总结文思内酰胺的化学性质、其合成用途以及近十年来在有机化学和药物化学中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Application of 2-Azabicyclo[2.2.1]Hept-5-En-3-One (Vince Lactam) in Synthetic Organic and Medicinal Chemistry

2-Azabicyclo[2.2.1]hept-5-en-3-one (Vince lactam) is known to be a valuable building block in synthetic organic chemistry and drug research. It is an important precursor to access of some blockbuster antiviral drugs such as Carbovir or Abacavir as well as other carbocyclic neuraminidase inhibitors as antiviral agents. The ring C=C bond of the Vince lactam allows versatile chemical manipulations to create not only functionalized γ-lactams, but also γ-amino acid derivatives with a cyclopentane framework. The aim of the current account is to summarize the chemistry of Vince lactam, its synthetic utility and application in organic and medicinal chemistry over the last decade.

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来源期刊

Chemical record 化学-化学综合

CiteScore

11.00

自引率

3.00%

发文量

188

审稿时长

>12 weeks

期刊介绍： The Chemical Record (TCR) is a "highlights" journal publishing timely and critical overviews of new developments at the cutting edge of chemistry of interest to a wide audience of chemists (2013 journal impact factor: 5.577). The scope of published reviews includes all areas related to physical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, polymer chemistry, materials chemistry, bioorganic chemistry, biochemistry, biotechnology and medicinal chemistry as well as interdisciplinary fields. TCR provides carefully selected highlight papers by leading researchers that introduce the author''s own experimental and theoretical results in a framework designed to establish perspectives with earlier and contemporary work and provide a critical review of the present state of the subject. The articles are intended to present concise evaluations of current trends in chemistry research to help chemists gain useful insights into fields outside their specialization and provide experts with summaries of recent key developments.