Mohammad Shakil Ahmad, Yousef Abud Alanazi, Yousef Alrohaimi, Riyaz Ahamed Shaik, Sami Alrashidi, Yazeed A Al-Ghasham, Yasir S Alkhalifah, Ritu Kumar Ahmad
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引用次数: 0
摘要
这项研究采用蒙特卡洛模拟法评估风险，回顾了全球婴儿配方奶粉和谷物食品中的赭曲霉毒素 A (OTA) 含量。截至 2024 年 3 月，本研究利用 PubMed、Scopus、Web of Science 和 Embase 等数据库，对全球婴儿食品和谷类食品中的 OTA 含量进行了 24 项研究。我们根据浓度、摄入量和体重估算了婴儿食品中的 OTA 暴露量。使用 BMDL10 和 TDI 值计算了暴露量和危害商差。蒙特卡洛模拟评估了婴儿配方奶粉和谷类食品中 OTA 对人体健康造成的风险。一项来自 14 个国家的全球研究显示，这些国家的 OTA 含量各不相同，突尼斯、厄瓜多尔和美国的 OTA 含量超过了欧盟规定的限值，非洲国家的 OTA 含量也普遍超过了欧盟规定的限值，尤其是婴儿谷物食品，其 OTA 含量高于配方奶粉。在全球分析的 3348 个样本中，29.3% 的样本含有 OTA，其中黎巴嫩为 95.2%，巴西为 0%。分析表明，OTA 对婴儿只有非致癌风险。虽然婴儿的健康风险大多较低，但持续的研究和监测对于最大限度地减少婴儿食品中的 OTA 暴露至关重要。
Occurrence, evaluation, and human health risk assessment of ochratoxin a in infant formula and cereal-based baby food: a global literature systematic review.
This study reviews global levels of ochratoxin A (OTA) in infant formula and cereal-based foods, using Monte Carlo simulation to assess risks. The review found 24 studies on global OTA levels in infant food and cereal-based products, using databases including PubMed, Scopus, Web of Science and Embase until March 2024. We estimated OTA exposure in infant food based on concentration, intake and body weight. The exposure and hazard quotient margin were calculated using BMDL10 and TDI values. Monte Carlo simulation evaluated human health risks from OTA in infant formula and cereal-based foods. A global study from 14 countries shows varying levels, surpassing EU limits in Tunisia, Ecuador, the USA, and generally in Africa, notably in infant cereals, which had higher levels than formula. Globally, OTA was present in 29.3% of the 3348 samples analyzed, with Lebanon at 95.2% and Brazil at 0%. Analysis indicates only non-carcinogenic risk for infants. While health risks for infants are mostly low, ongoing research and monitoring are vital to minimize OTA exposure in infant food.
期刊介绍：
Food Additives & Contaminants: Part A publishes original research papers and critical reviews covering analytical methodology, occurrence, persistence, safety evaluation, detoxification and regulatory control of natural and man-made additives and contaminants in the food and animal feed chain. Papers are published in the areas of food additives including flavourings, pesticide and veterinary drug residues, environmental contaminants, plant toxins, mycotoxins, marine biotoxins, trace elements, migration from food packaging, food process contaminants, adulteration, authenticity and allergenicity of foods. Papers are published on animal feed where residues and contaminants can give rise to food safety concerns. Contributions cover chemistry, biochemistry and bioavailability of these substances, factors affecting levels during production, processing, packaging and storage; the development of novel foods and processes; exposure and risk assessment.
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