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引用次数: 0
摘要
特定 T 淋巴细胞(T 细胞)系的形成受不同转录因子的支配,而转录因子的表达则通过表观遗传机制进行调节。揭示这些调控 T 细胞分化和功能的表观遗传机制对于了解 T 细胞具有重要意义。Menin是一种多功能支架蛋白,主要通过表观遗传机制参与细胞增殖、细胞周期控制、DNA修复和转录调控等多种细胞过程。现有研究表明,Menin 对 T 细胞的分化和功能有影响,但目前还缺乏全面系统的综述来整合这些发现。在本综述中,我们重点介绍了有关 Menin 在 T 细胞分化和功能中作用的最新研究,主要关注其对记忆 Th2 维持、Th17 分化和维持、CD4+ T 细胞衰老和效应 CD8+ T 细胞存活的影响。考虑到 Menin 在维持效应 T 细胞功能方面的关键作用,抑制 Menin 的活性在缓解与 T 细胞过度活化相关的炎症性疾病方面的潜力也得到了强调。
Roles of Menin in T cell differentiation and function: Current knowledge and perspectives
The commitment to specific T lymphocytes (T cell) lineages is governed by distinct transcription factors, whose expression is modulated through epigenetic mechanisms. Unravelling these epigenetic mechanisms that regulate T cell differentiation and function holds significant importance for understanding T cells. Menin, a multifunctional scaffolding protein, is implicated in various cellular processes, such as cell proliferation, cell cycle control, DNA repair and transcriptional regulation, primarily through epigenetic mechanisms. Existing research indicates Menin's impact on T cell differentiation and function, while a comprehensive and systematic review is currently lacking to consolidate these findings. In the current review, we have highlighted recent studies on the role of Menin in T cell differentiation and function, focusing mainly on its impact on the memory Th2 maintenance, Th17 differentiation and maintenance, CD4+ T cell senescence, and effector CD8+ T cell survival. Considering Menin's crucial function in maintaining effector T cell function, the potential of inhibiting Menin activity in mitigating inflammatory diseases associated with excessive T cell activation has also been emphasised.
期刊介绍:
Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers.
Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology.
The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.