镁与成年人的认知健康:系统回顾与元分析》。

IF 8 1区 医学 Q1 NUTRITION & DIETETICS Advances in Nutrition Pub Date : 2024-08-01 DOI:10.1016/j.advnut.2024.100272
Fan Chen , Jifan Wang , Yijie Cheng , Ruogu Li , Yifei Wang , Yutong Chen , Tammy Scott , Katherine L Tucker
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引用次数: 0

摘要

镁(Mg)在神经功能和表现中起着关键作用。然而,关于镁与成人认知健康的随机对照试验(RCT)和队列研究的证据尚未得到系统回顾。我们旨在通过总结随机对照试验和队列研究的证据,研究各种形式的镁(补充剂、膳食摄入量和生物标志物)与认知结果之间的关系。我们在PubMed、Embase、PsycINFO和Cochrane对照试验中央注册中心检索了截至2024年5月3日发表的相关同行评审文章。在适当的情况下,采用了三种随机效应模型来评估镁与认知结果之间的关系:1)线性元回归;2)非线性(二次)元回归;3)使用根据已有建议分类的镁变量进行元分析。本系统综述纳入了 3 项研究性试验和 12 项队列研究。有限的研究性试验所提供的证据不足以就镁补充剂的效果得出结论。队列研究显示,膳食镁与认知障碍之间的剂量-反应关系不一致,不同人群之间的异质性很高。然而,在队列研究中发现,血清镁与全因痴呆症和认知障碍之间存在一致的 U 型关系,表明最佳血清镁浓度约为 0.85 mmol/L。在元回归(Pquadratic = 0.003)和基于血清镁参考区间(0.75-0.95 mmol/L)的元分析中发现了这种非线性关联[0.95 与 0.85 mmol/L:汇总 HR = 1.30;95% CI = 1.03,1.64]。我们需要更多来自 RCT 和队列研究的证据。未来的队列研究应评估各种镁生物标志物,并在考虑不同来源(饮食或补充剂)和影响吸收的因素(如钙镁摄入比)的情况下,收集一段时间内镁摄入量的重复测量值。本系统综述已在 PROSPERO(CRD42023423663)上预先注册。
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Magnesium and Cognitive Health in Adults: A Systematic Review and Meta-Analysis

Magnesium (Mg) plays a key role in neurological functioning and manifestations. However, the evidence from randomized controlled trials (RCTs) and cohorts on Mg and cognitive health among adults has not been systematically reviewed. We aimed to examine the associations of various Mg forms (supplements, dietary intake, and biomarkers) with cognitive outcomes by summarizing evidence from RCTs and cohorts. PubMed, Embase, PsycINFO, and the Cochrane Central Register of Controlled Trials were searched for relevant peer-reviewed articles published up to May 3, 2024. Three random-effects models were performed, when appropriate, to evaluate the relationship between Mg and cognitive outcomes: 1) linear meta-regression, 2) nonlinear (quadratic) meta-regression, and 3) meta-analysis using Mg variables categorized based on pre-existing recommendations. Three RCTs and 12 cohort studies were included in this systematic review. Evidence from the limited number of RCTs was insufficient to draw conclusions on the effects of Mg supplements. Cohort studies showed inconsistent dose–response relationships between dietary Mg and cognitive disorders, with high heterogeneity across populations. However, consistent U-shape associations of serum Mg with all-cause dementia and cognitive impairment were found in cohorts, suggesting an optimal serum Mg concentration of ∼0.85 mmol/L. This nonlinear association was detected in meta-regression (Pquadratic = 0.003) and in meta-analysis based on the reference interval of serum Mg (0.75–0.95 mmol/L) [<0.75 compared with 0.85 mmol/L: pooled hazard ratio (HR) = 1.43; 95% confidence interval (CI) = 1.05, 1.93; >0.95 compared with 0.85 mmol/L: pooled HR = 1.30; 95% CI = 1.03, 1.64]. More evidence from RCTs and cohorts is warranted. Future cohort studies should evaluate various Mg biomarkers and collect repeated measurements of Mg intake over time, considering different sources (diet or supplements) and factors affecting absorption (for example, calcium-to-Mg intake ratio). This systematic review was preregistered in PROSPERO (CRD42023423663).

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来源期刊
Advances in Nutrition
Advances in Nutrition 医学-营养学
CiteScore
17.40
自引率
2.20%
发文量
117
审稿时长
56 days
期刊介绍: Advances in Nutrition (AN/Adv Nutr) publishes focused reviews on pivotal findings and recent research across all domains relevant to nutritional scientists and biomedical researchers. This encompasses nutrition-related research spanning biochemical, molecular, and genetic studies using experimental animal models, domestic animals, and human subjects. The journal also emphasizes clinical nutrition, epidemiology and public health, and nutrition education. Review articles concentrate on recent progress rather than broad historical developments. In addition to review articles, AN includes Perspectives, Letters to the Editor, and supplements. Supplement proposals require pre-approval by the editor before submission. The journal features reports and position papers from the American Society for Nutrition, summaries of major government and foundation reports, and Nutrient Information briefs providing crucial details about dietary requirements, food sources, deficiencies, and other essential nutrient information. All submissions with scientific content undergo peer review by the Editors or their designees prior to acceptance for publication.
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