{"title":"光疗纳米粒子在癌症单一疗法或联合疗法中的最新进展和临床挑战","authors":"","doi":"10.1016/j.ccr.2024.216069","DOIUrl":null,"url":null,"abstract":"<div><p>In the past decades, phototherapy has been explored in the field of cancer treatment owing to its advantages of high selectivity, excellent efficiency, and negligible drug resistance. Phototherapy relies on agents that generate hyperthermia or reactive oxygen species to allow specific targeting and tumor ablation. However, mono-phototherapy only shows modest efficiency, which cannot fight recalcitrant tumors completely and is usually accompanied by recurrence or metastasis, especially in clinics. Therefore, combining other therapeutic strategies (e.g., chemotherapy, radiotherapy, immunotherapy, gene therapy, anti-angiogenesis therapy, sonodynamic therapy, gas therapy, chemodynamic therapy, and starvation therapy) or novel modifications with phototherapy greatly increases clinical therapeutic potential and opens new horizons in oncology treatment. This review outlines the latest advances in phototherapeutic-based nanoparticles to fight cancer and their preclinical and clinical developments. First, cancer mono-phototherapy is summarized. Subsequently, phototherapy strategies combined with other therapeutic methods are reviewed. Finally, major challenges and perspectives of cancer phototherapy are discussed. This review provides a detailed introduction to cancer phototherapy and the combination strategies that promote significant remediation for future clinical translation.</p></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":null,"pages":null},"PeriodicalIF":20.3000,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent advances and clinical challenges of phototherapeutic nanoparticles in cancer monotherapy or combination therapy\",\"authors\":\"\",\"doi\":\"10.1016/j.ccr.2024.216069\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In the past decades, phototherapy has been explored in the field of cancer treatment owing to its advantages of high selectivity, excellent efficiency, and negligible drug resistance. Phototherapy relies on agents that generate hyperthermia or reactive oxygen species to allow specific targeting and tumor ablation. However, mono-phototherapy only shows modest efficiency, which cannot fight recalcitrant tumors completely and is usually accompanied by recurrence or metastasis, especially in clinics. Therefore, combining other therapeutic strategies (e.g., chemotherapy, radiotherapy, immunotherapy, gene therapy, anti-angiogenesis therapy, sonodynamic therapy, gas therapy, chemodynamic therapy, and starvation therapy) or novel modifications with phototherapy greatly increases clinical therapeutic potential and opens new horizons in oncology treatment. This review outlines the latest advances in phototherapeutic-based nanoparticles to fight cancer and their preclinical and clinical developments. First, cancer mono-phototherapy is summarized. Subsequently, phototherapy strategies combined with other therapeutic methods are reviewed. Finally, major challenges and perspectives of cancer phototherapy are discussed. This review provides a detailed introduction to cancer phototherapy and the combination strategies that promote significant remediation for future clinical translation.</p></div>\",\"PeriodicalId\":289,\"journal\":{\"name\":\"Coordination Chemistry Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":20.3000,\"publicationDate\":\"2024-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Coordination Chemistry Reviews\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0010854524004156\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coordination Chemistry Reviews","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010854524004156","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Recent advances and clinical challenges of phototherapeutic nanoparticles in cancer monotherapy or combination therapy
In the past decades, phototherapy has been explored in the field of cancer treatment owing to its advantages of high selectivity, excellent efficiency, and negligible drug resistance. Phototherapy relies on agents that generate hyperthermia or reactive oxygen species to allow specific targeting and tumor ablation. However, mono-phototherapy only shows modest efficiency, which cannot fight recalcitrant tumors completely and is usually accompanied by recurrence or metastasis, especially in clinics. Therefore, combining other therapeutic strategies (e.g., chemotherapy, radiotherapy, immunotherapy, gene therapy, anti-angiogenesis therapy, sonodynamic therapy, gas therapy, chemodynamic therapy, and starvation therapy) or novel modifications with phototherapy greatly increases clinical therapeutic potential and opens new horizons in oncology treatment. This review outlines the latest advances in phototherapeutic-based nanoparticles to fight cancer and their preclinical and clinical developments. First, cancer mono-phototherapy is summarized. Subsequently, phototherapy strategies combined with other therapeutic methods are reviewed. Finally, major challenges and perspectives of cancer phototherapy are discussed. This review provides a detailed introduction to cancer phototherapy and the combination strategies that promote significant remediation for future clinical translation.
期刊介绍:
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.