{"title":"含苯并噻唑-恶唑-吡嗪的查尔酮官能团作为抗癌剂的设计、合成和抗癌评估","authors":"P. Venkata Ramana Reddy , Dasari Sravani , Dittakavi Ramachandran , Ponnuri Bharath","doi":"10.1016/j.cdc.2024.101153","DOIUrl":null,"url":null,"abstract":"<div><p>A new library of chalcone functionality bearing benzothiazol-oxazole-pyrazine (<strong>10a-j</strong>) derivatives were designed, synthesized and screened for their anticancer activity against four human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) & A2780 (ovarian cancer) by employing the MTT assay. The results were compared with the etoposide used as a positive control. Most of the tested compounds displayed good to moderate activity compared to etoposide. Among them, compound <strong>10j</strong> showed potent anticancer activity against MCF-7, A549, Colo-205, and A2780 cell lines with IC<sub>50</sub> values of 0.01 ± 0.0073 µM, 0.03 ± 0.0087 µM, 0.06 ± 0.0066 µM, and 0.13 ± 0.055 µM respectively</p></div>","PeriodicalId":269,"journal":{"name":"Chemical Data Collections","volume":"52 ","pages":"Article 101153"},"PeriodicalIF":2.2180,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design, synthesis and anticancer evaluation of chalcone functionality bearing benzothiazol-oxazole-pyrazine as anticancer agents\",\"authors\":\"P. Venkata Ramana Reddy , Dasari Sravani , Dittakavi Ramachandran , Ponnuri Bharath\",\"doi\":\"10.1016/j.cdc.2024.101153\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A new library of chalcone functionality bearing benzothiazol-oxazole-pyrazine (<strong>10a-j</strong>) derivatives were designed, synthesized and screened for their anticancer activity against four human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) & A2780 (ovarian cancer) by employing the MTT assay. The results were compared with the etoposide used as a positive control. Most of the tested compounds displayed good to moderate activity compared to etoposide. Among them, compound <strong>10j</strong> showed potent anticancer activity against MCF-7, A549, Colo-205, and A2780 cell lines with IC<sub>50</sub> values of 0.01 ± 0.0073 µM, 0.03 ± 0.0087 µM, 0.06 ± 0.0066 µM, and 0.13 ± 0.055 µM respectively</p></div>\",\"PeriodicalId\":269,\"journal\":{\"name\":\"Chemical Data Collections\",\"volume\":\"52 \",\"pages\":\"Article 101153\"},\"PeriodicalIF\":2.2180,\"publicationDate\":\"2024-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Data Collections\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405830024000417\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Chemistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Data Collections","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405830024000417","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Chemistry","Score":null,"Total":0}
Design, synthesis and anticancer evaluation of chalcone functionality bearing benzothiazol-oxazole-pyrazine as anticancer agents
A new library of chalcone functionality bearing benzothiazol-oxazole-pyrazine (10a-j) derivatives were designed, synthesized and screened for their anticancer activity against four human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) & A2780 (ovarian cancer) by employing the MTT assay. The results were compared with the etoposide used as a positive control. Most of the tested compounds displayed good to moderate activity compared to etoposide. Among them, compound 10j showed potent anticancer activity against MCF-7, A549, Colo-205, and A2780 cell lines with IC50 values of 0.01 ± 0.0073 µM, 0.03 ± 0.0087 µM, 0.06 ± 0.0066 µM, and 0.13 ± 0.055 µM respectively
期刊介绍：
Chemical Data Collections (CDC) provides a publication outlet for the increasing need to make research material and data easy to share and re-use. Publication of research data with CDC will allow scientists to: -Make their data easy to find and access -Benefit from the fast publication process -Contribute to proper data citation and attribution -Publish their intermediate and null/negative results -Receive recognition for the work that does not fit traditional article format. The research data will be published as ''data articles'' that support fast and easy submission and quick peer-review processes. Data articles introduced by CDC are short self-contained publications about research materials and data. They must provide the scientific context of the described work and contain the following elements: a title, list of authors (plus affiliations), abstract, keywords, graphical abstract, metadata table, main text and at least three references. The journal welcomes submissions focusing on (but not limited to) the following categories of research output: spectral data, syntheses, crystallographic data, computational simulations, molecular dynamics and models, physicochemical data, etc.
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