运动训练和施沛欣可改善肥胖 2 型糖尿病大鼠的甲状腺变化:可能的相互作用机制。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM American journal of physiology. Endocrinology and metabolism Pub Date : 2024-09-01 Epub Date: 2024-07-17 DOI:10.1152/ajpendo.00213.2024
Fatma H Rizk, Ramez A E Barhoma, Mervat H El-Saka, Hoda A Ibrahim, Rehab M El-Gohary, Radwa Ismail, Shaimaa M Motawea, Ola Salem, Islam Ibrahim Hegab
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引用次数: 0

摘要

甲状腺功能障碍和糖尿病是常见的内分泌疾病,两者常常同时存在并相互影响。spexin(SPX)在糖尿病和肥胖症中的作用已被证实,但其与甲状腺功能的关系却鲜为人知。本研究调查了运动(EX)和SPX对肥胖2型糖尿病大鼠甲状腺功能减退的影响。大鼠被分为正常对照组、肥胖糖尿病静坐组、肥胖糖尿病EX组和肥胖糖尿病SPX组,后两组再细分为M871和HT-2157治疗组。高脂饮食和链脲佐菌素注射诱发肥胖和糖尿病。EX组进行游泳,而SPX组则接受为期八周的SPX注射。结果显示,EX和SPX治疗可明显改善甲状腺功能、代谢、氧化和炎症状态。研究还探讨了加兰宁受体同工酶(GALR)2/3参与SPX对甲状腺功能的影响。阻断GALR2/3受体可部分减弱其有益作用,这表明它们之间存在相互作用。这些发现强调了EX和SPX在调节肥胖症和糖尿病患者甲状腺功能方面的重要性。了解这种相互作用有助于开发治疗与肥胖型2型糖尿病相关的甲状腺疾病的新方法。要弄清SPX、EX活性和甲状腺功能之间的确切机制,还需要进行更多的研究。
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Exercise training and spexin ameliorate thyroid changes in obese type 2 diabetic rats: the possible interlaying mechanisms.

Thyroid dysfunction and diabetes mellitus are prevalent endocrine disorders that often coexist and influence each other. The role of spexin (SPX) in diabetes and obesity is well documented, but its connection to thyroid function is less understood. This study investigates the influence of exercise (EX) and SPX on thyroid hypofunction in obese type 2 diabetic rats. Rats were divided into normal control, obese diabetic sedentary, obese diabetic EX, and obese diabetic SPX groups, with subdivisions for M871 and HT-2157 treatment in the latter two groups. High-fat diet together with streptozotocin (STZ) injection induced obesity and diabetes. The EX group underwent swimming, and the SPX group received SPX injections for 8 wk. Results showed significant improvements in thyroid function and metabolic, oxidative, and inflammatory states with EX and SPX treatment. The study also explored the involvement of galanin receptor isoforms (GALR)2/3 in SPX effects on thyroid function. Blocking GALR2/3 receptors partially attenuated the beneficial effects, indicating their interaction. These findings underscore the importance of EX and SPX in modulating thyroid function in obesity and diabetes. Comprehending this interplay could enable the development of new treatment approaches for thyroid disorders associated with obese type 2 diabetes. Additional research is necessary to clarify the exact mechanisms connecting SPX, EX activity, and thyroid function.NEW & NOTEWORTHY This study proves, for the first time, the beneficial effects of SPX on thyroid dysfunction in obese diabetic rats and suggests that SPX mediates the EX effect on thyroid gland and exerts its effect mainly via GALR2.

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来源期刊
CiteScore
9.80
自引率
0.00%
发文量
98
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Endocrinology and Metabolism publishes original, mechanistic studies on the physiology of endocrine and metabolic systems. Physiological, cellular, and molecular studies in whole animals or humans will be considered. Specific themes include, but are not limited to, mechanisms of hormone and growth factor action; hormonal and nutritional regulation of metabolism, inflammation, microbiome and energy balance; integrative organ cross talk; paracrine and autocrine control of endocrine cells; function and activation of hormone receptors; endocrine or metabolic control of channels, transporters, and membrane function; temporal analysis of hormone secretion and metabolism; and mathematical/kinetic modeling of metabolism. Novel molecular, immunological, or biophysical studies of hormone action are also welcome.
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