口腔鳞状细胞癌中中性粒细胞与淋巴细胞比值（NLR）的预后意义

Oral Oncology Reports Pub Date : 2024-07-14 DOI:10.1016/j.oor.2024.100604

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引用次数: 0

摘要

背景肿瘤微环境是癌症进展过程中逃避研究的因素之一。本研究旨在评估口腔鳞状细胞癌组的 NLR 比率，并将其与正常对照组和恶性肿瘤前期组的 NLR 比率进行比较。评估了 NLR 与临床病理变量之间的关系。比较变量时采用 Tukey's 事后检验。结果评估并比较了三组患者的 NLR 比率。口腔鳞状细胞癌患者的平均 NLR 比值为 3.79，白斑病患者为 2.62，正常对照组为 2.07。NLR的升高还与肿瘤的晚期分期和分级有关。

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Prognostic significance of neutrophil to lymphocyte ratio (NLR) in oral squamous cell carcinoma

Background

Tumor microenvironment is one of the evading research in the progression of cancers. Circulating neutrophils reflect the system's inflammatory response and study the growth of tumor cells thereby inducing cancer progression.

Aim and objectives

The current study aims to evaluate the NLR ratio in oral squamous cell carcinoma group and to compare it with that of normal control and Premalignant group.

Material and methods

This study is retrospective, the medical records of 48 OSCC patients, 48 Leukoplakia patients, and 48 normal healthy controls were taken. Association between NLR and clinicopathological variables were assessed. Tukey's post-hoc test was done to compare the variables. Kaplan Meier analysis was done for the analysis of overall survival.

Results

The NLR ratio was assessed and compared between the three groups. The mean NLR ratio was found to be 3.79 in Oral squamous cell carcinoma patients, 2.62 in leukoplakia patients, and 2.07 in the normal control group.