{"title":"来自湛江异螯虾的抗氧化肽 ETT 可通过维持体内平衡和促进胶原蛋白生成来延缓皮肤衰老","authors":"","doi":"10.1016/j.algal.2024.103615","DOIUrl":null,"url":null,"abstract":"<div><p>ETT (Glu-Met-Phe-Gly-Thr-Ser-Ser-Glu-Thr) isolated from <em>Isochrysis zhanjiangensis</em> was an antioxidant nonapeptide with the highest active site on Met 2. In this study, the investigated the anti-skin aging effect of ETT on both keratinocytes and fibroblasts, took ultraviolet B (UVB)-induced human immortalized keratinocytes (HaCaT) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced human skin fibroblasts (BJ cells). The results showed the anti-photoaging effect of ETT on UVB-induced HaCaT cells by declining an increasing level of intracellular reactive oxygen species (ROS), activating antioxidant system via nuclear factor erythroid 2 (Nrf2)/ heme oxgenase-1 (HO-1) signaling pathway, promoting autophagy to enhancing mitochondrial membrane potential and inhibiting apoptosis. Moreover, ETT also against skin aging on H<sub>2</sub>O<sub>2</sub>-induced BJ cells by attenuating senescence and improving collagen generation via transforming growth factor β1 (TGF-β1)/Smad signaling pathway. In general, these results indicated ETT is potential to against skin aging by maintaining keratinocytes homeostasis, reducing apoptosis, attenuating fibroblasts senescence and enhancing content of collagen.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antioxidant peptide ETT from Isochrysis zhanjiangensis attenuate skin aging by maintaining homeostasis and promoting collagen generation\",\"authors\":\"\",\"doi\":\"10.1016/j.algal.2024.103615\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>ETT (Glu-Met-Phe-Gly-Thr-Ser-Ser-Glu-Thr) isolated from <em>Isochrysis zhanjiangensis</em> was an antioxidant nonapeptide with the highest active site on Met 2. In this study, the investigated the anti-skin aging effect of ETT on both keratinocytes and fibroblasts, took ultraviolet B (UVB)-induced human immortalized keratinocytes (HaCaT) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced human skin fibroblasts (BJ cells). The results showed the anti-photoaging effect of ETT on UVB-induced HaCaT cells by declining an increasing level of intracellular reactive oxygen species (ROS), activating antioxidant system via nuclear factor erythroid 2 (Nrf2)/ heme oxgenase-1 (HO-1) signaling pathway, promoting autophagy to enhancing mitochondrial membrane potential and inhibiting apoptosis. Moreover, ETT also against skin aging on H<sub>2</sub>O<sub>2</sub>-induced BJ cells by attenuating senescence and improving collagen generation via transforming growth factor β1 (TGF-β1)/Smad signaling pathway. In general, these results indicated ETT is potential to against skin aging by maintaining keratinocytes homeostasis, reducing apoptosis, attenuating fibroblasts senescence and enhancing content of collagen.</p></div>\",\"PeriodicalId\":7855,\"journal\":{\"name\":\"Algal Research-Biomass Biofuels and Bioproducts\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Algal Research-Biomass Biofuels and Bioproducts\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2211926424002273\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Algal Research-Biomass Biofuels and Bioproducts","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211926424002273","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Antioxidant peptide ETT from Isochrysis zhanjiangensis attenuate skin aging by maintaining homeostasis and promoting collagen generation
ETT (Glu-Met-Phe-Gly-Thr-Ser-Ser-Glu-Thr) isolated from Isochrysis zhanjiangensis was an antioxidant nonapeptide with the highest active site on Met 2. In this study, the investigated the anti-skin aging effect of ETT on both keratinocytes and fibroblasts, took ultraviolet B (UVB)-induced human immortalized keratinocytes (HaCaT) and hydrogen peroxide (H2O2)-induced human skin fibroblasts (BJ cells). The results showed the anti-photoaging effect of ETT on UVB-induced HaCaT cells by declining an increasing level of intracellular reactive oxygen species (ROS), activating antioxidant system via nuclear factor erythroid 2 (Nrf2)/ heme oxgenase-1 (HO-1) signaling pathway, promoting autophagy to enhancing mitochondrial membrane potential and inhibiting apoptosis. Moreover, ETT also against skin aging on H2O2-induced BJ cells by attenuating senescence and improving collagen generation via transforming growth factor β1 (TGF-β1)/Smad signaling pathway. In general, these results indicated ETT is potential to against skin aging by maintaining keratinocytes homeostasis, reducing apoptosis, attenuating fibroblasts senescence and enhancing content of collagen.
期刊介绍：
Algal Research is an international phycology journal covering all areas of emerging technologies in algae biology, biomass production, cultivation, harvesting, extraction, bioproducts, biorefinery, engineering, and econometrics. Algae is defined to include cyanobacteria, microalgae, and protists and symbionts of interest in biotechnology. The journal publishes original research and reviews for the following scope: algal biology, including but not exclusive to: phylogeny, biodiversity, molecular traits, metabolic regulation, and genetic engineering, algal cultivation, e.g. phototrophic systems, heterotrophic systems, and mixotrophic systems, algal harvesting and extraction systems, biotechnology to convert algal biomass and components into biofuels and bioproducts, e.g., nutraceuticals, pharmaceuticals, animal feed, plastics, etc. algal products and their economic assessment
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