评估全身振动的抗炎效果:基于临床前和临床证据的荟萃分析。

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2024-06-25 eCollection Date: 2024-01-01 DOI:10.62347/LLGY4023
Yiying Wang, Renxin Ji, Bo Yu
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引用次数: 0

摘要

背景:全身振动(WBV)是一种常用的疾病预防和康复体育锻炼方法。最近的研究表明,全身振动的有益机制可能与它的抗炎潜力有关,但它对不同炎症介质的调节作用仍存在争议。本研究旨在进行一项荟萃分析,以重新确认 WBV 运动对各种炎症因子的影响:方法:检索 PubMed、EMBASE 和 Cochrane Library 数据库,收集截至 2023 年 9 月所有比较 WBV 与对照(或后-前试验)的文章。效应大小以标准化平均差异(SMD)和 95% 置信区间(CI)表示:结果:共纳入了 31 项符合条件的研究,包括 14 项临床前研究和 17 项临床研究。临床前研究的荟萃分析表明,与对照组相比,WBV 运动能显著降低 IL-6 (SMD:-1.03,95% CI:-1.93,-0.13)、TNF-α (SMD:-1.36,95% CI:-2.54,-0.17)(疾病亚组)、IL-1β(SMD:-2.20,95% CI:-3.24,-1.15)、IFN-γ(SMD:-1.91,95% CI:-2.71,-1.12)、IL-4(SMD:-0.71,95% CI:-1.39,-0.03)和 IL-17(SMD:-1.32,95% CI:-2.05,-0.59)。对临床研究进行汇总后发现,WBV 运动能显著降低 TNF-α 的水平(WBV 与对照组相比,SMD:-1.11,95% CI:-1.39,-0.03):SMD:-1.11,95% CI:-2.16,-0.06;后与前:SMD:-1.29,95% CI:-1.91,-0.67)、CRP(SMD:-3.59,95% CI:-6.36,-0.82,P = 0.011)的水平,并提高了 IL-10 的水平(WBV 与对照组相比,SMD:2.90,95% CI:-2.05,-0.59):SMD:2.90,95% CI:1.10,4.71;后与前:SMD:1.75,95% CI:0.64,2.87)和 IL-6(SMD:0.91,95% CI:0.31,1.52)(健康亚组):WBV可能是预防和康复炎症性疾病的有效工具。
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Assessing the anti-inflammatory effects of whole-body vibration: a meta-analysis based on pre-clinical and clinical evidences.

Background: Whole-body vibration (WBV) is a commonly used physical exercise for disease prevention and rehabilitation. Recent studies indicated the beneficial mechanism of WBV may be associated with its anti-inflammatory potential, however, its regulatory roles on different inflammatory mediators remained controversial. The aim of this study was to perform a meta-analysis to re-confirm the effects of WBV exercise on various inflammatory factors.

Methods: The PubMed, EMBASE and Cochrane Library databases were searched up to September 2023 to collect all articles comparing WBV with control (or post-pre trials). The effect size was expressed as the standardized mean difference (SMD) and 95% confidence intervals (CI).

Results: A total of 31 eligible studies were included, including 14 pre-clinical and 17 clinical studies. The meta-analysis of pre-clinical studies showed that compared with the control group, WBV exercise could significantly reduce the level of IL-6 (SMD: -1.03, 95% CI: -1.93, -0.13), TNF-α (SMD: -1.36, 95% CI: -2.54, -0.17) (for disease subgroup), IL-1β (SMD: -2.20, 95% CI: -3.24, -1.15), IFN-γ (SMD: -1.91, 95% CI: -2.71, -1.12), IL-4 (SMD: -0.71, 95% CI: -1.39, -0.03) and IL-17 (SMD: -1.32, 95% CI: -2.05, -0.59) overall. Pooling of clinical studies revealed WBV exercise significantly reduced the level of TNF-α (WBV vs control: SMD: -1.11, 95% CI: -2.16, -0.06; post vs pre: SMD: -1.29, 95% CI: -1.91, -0.67), CRP (SMD: -3.59, 95% CI: -6.36, -0.82, P = 0.011) and enhanced the level of IL-10 (WBV vs control: SMD: 2.90, 95% CI: 1.10, 4.71; post vs pre: SMD: 1.75, 95% CI: 0.64, 2.87) and IL-6 (SMD: 0.91, 95% CI: 0.31, 1.52) (healthy subgroup).

Conclusion: WBV may be an effective prevention and rehabilitation tool for inflammatory diseases.

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