急性肾损伤的遗传风险：逐个研究 SNP

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY Kidney international Pub Date : 2024-07-18 DOI:10.1016/j.kint.2024.05.011

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引用次数: 0

摘要

这篇评论论述了本期报道的急性肾损伤（AKI）全基因组关联研究的一些优点、缺点和挑战。这项 AKI 全基因组关联研究执行得很好，在发现两个全基因组重要位点方面取得了重大进展。然而，由于 AKI 表型的临床异质性，加上指数住院风险和 AKI 风险之间的遗传相关性可能导致的偏差，因此需要在方法上取得进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acute kidney injury genetic risks: taking it 1 SNP at a time

This commentary addresses some of the strengths, shortcomings, and challenges of the genome-wide association study of acute kidney injury (AKI) report in this issue. This AKI genome-wide association study is well executed and provides significant progress in finding 2 genome-wide significant loci. However, significant interpretive challenges remain, where advancements in methods are needed because of the clinical heterogeneity of the AKI phenotype, plus possible bias due to genetic correlation between index hospitalization risk and AKI risk.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.