壳聚糖纳米生物聚合物输送亚麻:增强对多囊卵巢综合征的疗效

IF 3.8 4区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS IET nanobiotechnology Pub Date : 2024-07-17 DOI:10.1049/2024/6693566
Abolfazl Bayrami, Maryam Sojoudi, Shima Rahim Pouran, Aziz Habibi-Yangjeh, Sanaz Sojoudi
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引用次数: 0

摘要

在此,壳聚糖纳米颗粒(CHIT)被用作一种安全且具有生物相容性的基质来承载亚麻籽(Linum usitatissimum L.)提取物(FSE)。通过 SEM、DLS、FTIR、XRD、TGA 和 zeta 电位分析确定了 CHIT-FSE 的主要特征数量和生物表面特性,并与缺乏 FSE 的壳聚糖进行了比较。还进行了气相色谱-质谱分析,以揭示 FSE 的生物活性化合物。结果表明,FSE 植物大分子在壳聚糖纳米粒子上的活性锚定增强了热稳定性和结构稳定性。随后,评估了补充 CHIT-FSE、CHIT-TPP 和 FSE 对雌性大鼠多囊卵巢综合征(PCOS)激素和生化指标的影响,并与未处理组和健康对照组进行了比较。经过 16 天的治疗后,CHIT-FSE 在控制所研究的生化(血脂和血糖水平)和激素(胰岛素、睾酮、促黄体生成素和促卵泡激素)参数的血清水平方面表现最佳。考虑到 CHIT-TPP 的治疗活性微乎其微,CHIT-FSE 的活性比仅 FSE 的活性更强,这是基于壳聚糖纳米颗粒在增强具有重要治疗作用的植物大分子的稳定性、生物利用度、运输和渗透性方面的强大作用。根据这项研究的结果,通过壳聚糖支持具有重要医疗价值的生物大分子可以提高其在控制多囊卵巢综合症方面的治疗效果。
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Linum usitatissimum Delivery over Chitosan Nanobiopolymer: Enhanced Effects on Polycystic Ovary Syndrome Condition

Herein, chitosan nanoparticle (CHIT) was used as a safe and biocompatible matrix to carry flaxseed (Linum usitatissimum L.) extract (FSE). The number of main features and bio-interface properties of CHIT-FSE were determined by SEM, DLS, FTIR, XRD, TGA, and zeta potential analyses and compared to those of chitosan lacking FSE. A GC–MS analysis was also conducted to reveal the bioactive compounds of FSE. The active anchoring of the FSE phytomolecules over chitosan nanoparticles with enhanced thermal and structural stability was correspondingly verified. Subsequently, the influence of CHIT-FSE, CHIT-TPP, and FSE supplementation was assessed on hormonal and biochemical markers of polycystic ovary syndrome (PCOS) in female rats and compared with untreated and healthy control groups. After 16 days of treatment, CHIT-FSE represented the best performance for controlling the serum levels of the studied biochemical (lipid profile and blood glucose level) and hormonal (insulin, testosterone, luteinizing, and follicle-stimulating hormone) parameters. Considering the negligible therapeutic activity of CHIT-TPP, the enhanced activity of CHIT-FSE compared to only FSE was expounded based on the potent action of chitosan nanoparticles in enhanced stabilization, bioavailability, transport, and permeability of the therapeutically important phytomolecules. As per the results of this investigation, supporting medically important biomolecules over chitosan can enhance their therapeutic effectiveness in controlling PCOS.

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来源期刊
IET nanobiotechnology
IET nanobiotechnology 工程技术-纳米科技
CiteScore
6.20
自引率
4.30%
发文量
34
审稿时长
1 months
期刊介绍: Electrical and electronic engineers have a long and illustrious history of contributing new theories and technologies to the biomedical sciences. This includes the cable theory for understanding the transmission of electrical signals in nerve axons and muscle fibres; dielectric techniques that advanced the understanding of cell membrane structures and membrane ion channels; electron and atomic force microscopy for investigating cells at the molecular level. Other engineering disciplines, along with contributions from the biological, chemical, materials and physical sciences, continue to provide groundbreaking contributions to this subject at the molecular and submolecular level. Our subject now extends from single molecule measurements using scanning probe techniques, through to interactions between cells and microstructures, micro- and nano-fluidics, and aspects of lab-on-chip technologies. The primary aim of IET Nanobiotechnology is to provide a vital resource for academic and industrial researchers operating in this exciting cross-disciplinary activity. We can only achieve this by publishing cutting edge research papers and expert review articles from the international engineering and scientific community. To attract such contributions we will exercise a commitment to our authors by ensuring that their manuscripts receive rapid constructive peer opinions and feedback across interdisciplinary boundaries. IET Nanobiotechnology covers all aspects of research and emerging technologies including, but not limited to: Fundamental theories and concepts applied to biomedical-related devices and methods at the micro- and nano-scale (including methods that employ electrokinetic, electrohydrodynamic, and optical trapping techniques) Micromachining and microfabrication tools and techniques applied to the top-down approach to nanobiotechnology Nanomachining and nanofabrication tools and techniques directed towards biomedical and biotechnological applications (e.g. applications of atomic force microscopy, scanning probe microscopy and related tools) Colloid chemistry applied to nanobiotechnology (e.g. cosmetics, suntan lotions, bio-active nanoparticles) Biosynthesis (also known as green synthesis) of nanoparticles; to be considered for publication, research papers in this area must be directed principally towards biomedical research and especially if they encompass in vivo models or proofs of concept. We welcome papers that are application-orientated or offer new concepts of substantial biomedical importance Techniques for probing cell physiology, cell adhesion sites and cell-cell communication Molecular self-assembly, including concepts of supramolecular chemistry, molecular recognition, and DNA nanotechnology Societal issues such as health and the environment Special issues. Call for papers: Smart Nanobiosensors for Next-generation Biomedical Applications - https://digital-library.theiet.org/files/IET_NBT_CFP_SNNBA.pdf Selected extended papers from the International conference of the 19th Asian BioCeramic Symposium - https://digital-library.theiet.org/files/IET_NBT_CFP_ABS.pdf
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