CAR-T疗法中衔接疗法不断演变的作用

Shakthi T Bhaskar, B. Dholaria, B. Savani, Olalekan O. Oluwole
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引用次数: 0

摘要

嵌合抗原受体(CAR)T 细胞疗法已在一系列血液系统恶性肿瘤中得到广泛应用。尽管 CAR T 疗法改变了许多恶性肿瘤的治疗效果,但由于患者相关因素、社会障碍或保险问题导致治疗延迟,使治疗变得更加复杂。由于使用 CAR T 细胞治疗患者需要漫长的过程,因此在白细胞清除术后、CAR T 输注前进行的桥接疗法(BT)已成为安全使用 CAR T 疗法的重要组成部分。在此,我们回顾了支持使用桥接疗法的数据、选择患者时应考虑的因素、可用桥接疗法的类型以及选择这些疗法的理由。
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The Evolving Role of Bridging Therapy during CAR-T Therapy
Chimeric antigen receptor (CAR) T-cell therapy has gained wide used across an array of hematologic malignancies. Though CAR T therapy has changed outcomes in the treatment of many malignancies its administration can be complicated by delays related to patient-related factors, social barriers, or insurance issues. Because of the lengthy process required to treat a patient with CAR T-cells, bridging therapy (BT), administered after leukapheresis but prior to CAR T infusion, has become an important component of safely administering CAR T therapy. Here we review data supporting the use of BT, factors to consider in patient selection, and types of available BT and rationale for choosing amongst them.
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