Roberto Anaya-Prado, Ana P. Cárdenas-Fregoso, Ana M. Reyes-Perez, Danielle M Ortiz-Hernandez, Montserrat Quijano-Ortiz, Monica V Delgado-Martinez, Ana S Pelayo-Romo, Roberto Anaya-Fernández, M. Anaya-Fernández, Consuelo C Azcona-Ramirez, Ivan F Garcia-Ramirez, Miguel A. Guerrero-Palomera, Daniel Gonzalez-Martinez, Citlalli S Guerrero-Palomera, Karina Paredes-Paredes, Claudia Garcia-Perez
{"title":"肠道微生物群对神经系统疾病的生物分子基础","authors":"Roberto Anaya-Prado, Ana P. Cárdenas-Fregoso, Ana M. Reyes-Perez, Danielle M Ortiz-Hernandez, Montserrat Quijano-Ortiz, Monica V Delgado-Martinez, Ana S Pelayo-Romo, Roberto Anaya-Fernández, M. Anaya-Fernández, Consuelo C Azcona-Ramirez, Ivan F Garcia-Ramirez, Miguel A. Guerrero-Palomera, Daniel Gonzalez-Martinez, Citlalli S Guerrero-Palomera, Karina Paredes-Paredes, Claudia Garcia-Perez","doi":"10.21926/obm.neurobiol.2403232","DOIUrl":null,"url":null,"abstract":"The human gastrointestinal (GI) tract harbors many microorganisms, including viruses, protozoa, archaea, fungi, and bacteria. Altogether, these microbes constitute what we know as the gut microbiome (GM). These commensal communities have important implications for human health. They influence physiological processes through different mechanisms, including synthesizing neurotransmitters, regulating enzymatic pathways, and releasing molecules responsible for different signal pathways. The interaction between GM and brain function has been associated with the development and pathogenesis of neuropsychiatric diseases. This review discusses current studies targeting the regulation and modulation of GM in nerve, neuroendocrine, and immune pathways. Thus, we analyze current evidence on transcription, changes in composition, and specific interactions between the gut and brain from a biomolecular perspective. Special attention is paid to mood disorders and neurodegenerative diseases.","PeriodicalId":507111,"journal":{"name":"OBM Neurobiology","volume":"65 12","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Biomolecular Basis of Gut Microbiome on Neurological Diseases\",\"authors\":\"Roberto Anaya-Prado, Ana P. Cárdenas-Fregoso, Ana M. Reyes-Perez, Danielle M Ortiz-Hernandez, Montserrat Quijano-Ortiz, Monica V Delgado-Martinez, Ana S Pelayo-Romo, Roberto Anaya-Fernández, M. Anaya-Fernández, Consuelo C Azcona-Ramirez, Ivan F Garcia-Ramirez, Miguel A. Guerrero-Palomera, Daniel Gonzalez-Martinez, Citlalli S Guerrero-Palomera, Karina Paredes-Paredes, Claudia Garcia-Perez\",\"doi\":\"10.21926/obm.neurobiol.2403232\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The human gastrointestinal (GI) tract harbors many microorganisms, including viruses, protozoa, archaea, fungi, and bacteria. Altogether, these microbes constitute what we know as the gut microbiome (GM). These commensal communities have important implications for human health. They influence physiological processes through different mechanisms, including synthesizing neurotransmitters, regulating enzymatic pathways, and releasing molecules responsible for different signal pathways. The interaction between GM and brain function has been associated with the development and pathogenesis of neuropsychiatric diseases. This review discusses current studies targeting the regulation and modulation of GM in nerve, neuroendocrine, and immune pathways. Thus, we analyze current evidence on transcription, changes in composition, and specific interactions between the gut and brain from a biomolecular perspective. Special attention is paid to mood disorders and neurodegenerative diseases.\",\"PeriodicalId\":507111,\"journal\":{\"name\":\"OBM Neurobiology\",\"volume\":\"65 12\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"OBM Neurobiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21926/obm.neurobiol.2403232\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"OBM Neurobiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21926/obm.neurobiol.2403232","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Biomolecular Basis of Gut Microbiome on Neurological Diseases
The human gastrointestinal (GI) tract harbors many microorganisms, including viruses, protozoa, archaea, fungi, and bacteria. Altogether, these microbes constitute what we know as the gut microbiome (GM). These commensal communities have important implications for human health. They influence physiological processes through different mechanisms, including synthesizing neurotransmitters, regulating enzymatic pathways, and releasing molecules responsible for different signal pathways. The interaction between GM and brain function has been associated with the development and pathogenesis of neuropsychiatric diseases. This review discusses current studies targeting the regulation and modulation of GM in nerve, neuroendocrine, and immune pathways. Thus, we analyze current evidence on transcription, changes in composition, and specific interactions between the gut and brain from a biomolecular perspective. Special attention is paid to mood disorders and neurodegenerative diseases.