慢性肾病患者血清中 P-选择素的浓度

Kh.A. Rasulova, A. K. Abbasov
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引用次数: 0

摘要

背景。内皮功能障碍(ED)在慢性肾脏病(CKD)的发生和发展中起着重要作用。目的:研究 CKD 患者血液中 P 选择素的含量,并评估其对 ED 的发展和动脉粥样硬化变化的影响。根据 KDIGO(2012)的建议诊断为 CKD。血清中 P-选择素的浓度是通过固相酶联免疫法测定的,使用的试剂是 "Cloud-Clone Corp.P-selectin ELISA"(中国)。根据 CKD 阶段的不同,所有患者被分为 6 组。在 CKD C1 - C3a 阶段,血清中 P 选择素的浓度增加。从 CKD C3b 阶段开始,P-选择素的数值开始明显下降,尤其是在 C5d 阶段。血清中 P-选择素浓度的升高可作为对凝血图和血脂图参数进行深入动态监测的指征,而血清中 P-选择素浓度的降低则极有可能表明动脉床的几何形状发生了不良变化。在这方面,最好测定脉搏波速度和阿加特斯通指数。
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The concentration of P-selectin in the blood serum of patients with chronic kidney disease
BACKGROUND. Endothelial dysfunction (ED) plays an important role in the development and progression of chronic kidney disease (CKD). However, there is insufficient information in the literature on changes in the expression of vascular wall endothelial adhesive molecules in patients with kidney disease.THE AIM: to study the content of P-selectin in the blood of patients with CKD and to evaluate its effect on the development of ED and atherosclerotic changes.PATIENTS AND METHODS. 128 patients with CKD (41% of men and 59% of women) were monitored, with an average age of 63.5±1.7 years. The diagnosis of CKD was made in accordance with the recommendations of KDIGO (2012). The concentration in serum of P-selectin was determined by solid-phase enzyme immunoassay using a set of reagents "Cloud-Clone Corp. P-selectin ELISA" (China).RESULTS. All patients were divided into 6 groups depending on the stage of CKD. In CKD C1 - C3a stage, an increase in the concentration of P-selectin in blood serum was revealed. Starting from the C3b stage of CKD, the values of P-selectin begin to decrease significantly, especially sharply at the C5d stage.CONCLUSION. An increase in the concentration of P-selectin in blood serum can serve as an indication for in-depth dynamic monitoring of coagulogram and lipidogram parameters, a decrease in the concentration of P-selectin in blood serum is highly likely to indicate adverse changes in the geometry of the arterial bed. In this regard, it is advisable to determine the pulse wave velocity and the Agatston index. 
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