尿路微生物群和尿液蛋白质组在尿路结石发病机制中的作用

N. A. Verlov, V. Burdakov, L. A. Ivanova, I. A. Kulakov, A. A. Bogdanov, V. Emanuel
{"title":"尿路微生物群和尿液蛋白质组在尿路结石发病机制中的作用","authors":"N. A. Verlov, V. Burdakov, L. A. Ivanova, I. A. Kulakov, A. A. Bogdanov, V. Emanuel","doi":"10.36485/1561-6274-2024-28-2-85-93","DOIUrl":null,"url":null,"abstract":"The pathogenetic approach to the metaphylaxis of urolithiasis is universally a socially significant health problem due to the increase in morbidity and, especially, its recurrent course, despite the achievements of pharmacotherapy and the use of lithotripsy. Pathological crystallogenesis is considered as a consequence of exceeding the solubility threshold of a number of mineral components of urine, on the one hand, and as a consequence of posttranslational defects of the main proteome of urination - uromodulin (UMOD), demonstrating in healthy people a sanogenetic system for ensuring the stability of biophysical homeostasis: colloidal properties of urine. However, in addition, UMOD, by binding mannose-dependent pills of infectious agents, blocks the contact of bacteria with urotheliocytes, despite the fact that infection of the urinary tract is a known factor of urolithiasis. By modeling the urine of healthy individuals by coincubation with E. coli bacteria, a decrease in the concentration of polymerized uromodulin in urine was demonstrated as a factor in increasing the risk of formation of calcium oxalate crystals","PeriodicalId":19089,"journal":{"name":"Nephrology (Saint-Petersburg)","volume":"16 5","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of urinary tract microbiota and urine proteome in urolithiasis pathogenesis\",\"authors\":\"N. A. Verlov, V. Burdakov, L. A. Ivanova, I. A. Kulakov, A. A. Bogdanov, V. Emanuel\",\"doi\":\"10.36485/1561-6274-2024-28-2-85-93\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The pathogenetic approach to the metaphylaxis of urolithiasis is universally a socially significant health problem due to the increase in morbidity and, especially, its recurrent course, despite the achievements of pharmacotherapy and the use of lithotripsy. Pathological crystallogenesis is considered as a consequence of exceeding the solubility threshold of a number of mineral components of urine, on the one hand, and as a consequence of posttranslational defects of the main proteome of urination - uromodulin (UMOD), demonstrating in healthy people a sanogenetic system for ensuring the stability of biophysical homeostasis: colloidal properties of urine. However, in addition, UMOD, by binding mannose-dependent pills of infectious agents, blocks the contact of bacteria with urotheliocytes, despite the fact that infection of the urinary tract is a known factor of urolithiasis. By modeling the urine of healthy individuals by coincubation with E. coli bacteria, a decrease in the concentration of polymerized uromodulin in urine was demonstrated as a factor in increasing the risk of formation of calcium oxalate crystals\",\"PeriodicalId\":19089,\"journal\":{\"name\":\"Nephrology (Saint-Petersburg)\",\"volume\":\"16 5\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nephrology (Saint-Petersburg)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36485/1561-6274-2024-28-2-85-93\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nephrology (Saint-Petersburg)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36485/1561-6274-2024-28-2-85-93","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

尽管药物治疗和碎石技术已经取得了一定的成就,但由于发病率的增加,特别是反复发作的病程,尿路结石的病因学研究是一个具有普遍意义的社会健康问题。病理结晶一方面被认为是尿液中一些矿物质成分的溶解度超过阈值的结果,另一方面被认为是排尿的主要蛋白质组--尿调素(UMOD)翻译后缺陷的结果,尿调素在健康人体内展示了一个确保生物物理平衡稳定的卫生遗传系统:尿液的胶体特性。此外,尽管尿路感染是导致尿路结石的一个已知因素,但 UMOD 通过结合传染性病原体的甘露糖丸,阻止了细菌与尿路细胞的接触。通过对健康人的尿液与大肠杆菌共同作用进行建模,证明尿液中聚合尿泌素浓度的降低是增加草酸钙结晶形成风险的一个因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Role of urinary tract microbiota and urine proteome in urolithiasis pathogenesis
The pathogenetic approach to the metaphylaxis of urolithiasis is universally a socially significant health problem due to the increase in morbidity and, especially, its recurrent course, despite the achievements of pharmacotherapy and the use of lithotripsy. Pathological crystallogenesis is considered as a consequence of exceeding the solubility threshold of a number of mineral components of urine, on the one hand, and as a consequence of posttranslational defects of the main proteome of urination - uromodulin (UMOD), demonstrating in healthy people a sanogenetic system for ensuring the stability of biophysical homeostasis: colloidal properties of urine. However, in addition, UMOD, by binding mannose-dependent pills of infectious agents, blocks the contact of bacteria with urotheliocytes, despite the fact that infection of the urinary tract is a known factor of urolithiasis. By modeling the urine of healthy individuals by coincubation with E. coli bacteria, a decrease in the concentration of polymerized uromodulin in urine was demonstrated as a factor in increasing the risk of formation of calcium oxalate crystals
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
0.50
自引率
0.00%
发文量
0
期刊最新文献
The concentration of P-selectin in the blood serum of patients with chronic kidney disease Nutritional disorders and survival rate of elderly and geriatric patients with CKD 3B-5 stage Clinical signifi cance of various variants of euthyroid pathology syndrome in patients with end-stage chronic kidney disease on programmed hemodialysis Features of the course of the new coronavirus infection COVID-19 in patients with chronic kidney disease Role of urinary tract microbiota and urine proteome in urolithiasis pathogenesis
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1