使用洁面摩丝和非甾体乳液预防和治疗接受辅助放疗的乳腺癌患者急性放射性皮炎的初步经验

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cosmetics Pub Date : 2024-07-11 DOI:10.3390/cosmetics11040117
A. Viola, E. Martorana, Valentina Zagardo, G. Ferini
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引用次数: 0

摘要

背景:放射性皮炎(RD)是乳腺癌辅助放疗(RT)患者最常见的副作用。尽管新的放射治疗技术具有保护皮肤的优点,但大多数患者还是会患上放射性皮炎。目前还没有预防和舒缓 RD 的标准治疗方法,通常使用润肤剂、保湿剂或皮质类固醇激素来控制 RD。我们进行了一项前瞻性观察研究,以评估在接受手术的乳腺癌患者辅助 RT 计划中使用清洁摩丝和非类固醇乳液的 RD 发生率和等级。材料与方法:含有植物甘油(12%)、洋甘菊植物提取物(0.5%)、西洋蓍草植物提取物(0.5%)、甜杏仁(0.1%)、油橄榄油(0.1%)和大米蛋白水解物(0.1%)的洁面摩丝,以及含有微粉氧化锌(3.此外,还为接受辅助 RT 的乳腺癌患者提供了含有微粉氧化锌(3.7%)、油菜籽植物甾醇(1.7%)、芦荟(0.5%)、18-beta 甘草次酸(0.5%)、α-双羟基苯酚(0.5%)和黄烯(0.5%)的乳液,以预防 RD 的发生并减轻其严重程度。选择这些特定成分是因为它们具有众所周知的抗炎、抗氧化和保湿特性。对皮肤毒性进行拍照记录,并根据 RTOG 评分系统进行分级。结果从 2023 年 3 月到 2023 年 7 月,共有 24 名患者入组,中位年龄为 59 岁(42-75 岁不等)。在 RT 治疗中途,20 名患者(83.3%)出现 G0 皮肤毒性,3 名患者(12.5%)出现 G1,1 名患者(4.2%)出现 G2。没有人出现 G3-G4 级毒性。RT 结束时,7 名患者(29.2%)出现 G0 皮肤毒性,14 名患者(58.3%)出现 G1,2 名患者(8.3%)出现 G2,1 名患者(4.2%)出现 G3。没有患者出现 G4 毒性反应。RT 结束 15 天后,13 名患者(54.2%)出现 G0 皮肤毒性,10 名(41.1%)出现 G1,1 名(4.2%)出现 G2,没有人出现 G3-G4 毒性。结论我们的数据表明,测试的外用药可能是预防和缓解 RD 的有效选择。还需要进一步的前瞻性随机研究来证实我们的发现。
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Preliminary Experience with a Cleansing Mousse and a Non-Steroidal Emulsion for the Prevention and Treatment of Acute Radiation Dermatitis in Breast Cancer Patients Undergoing Adjuvant Radiotherapy
Background: Radiation dermatitis (RD) is the most frequent side effect in patients undergoing adjuvant radiotherapy (RT) for breast cancer. Despite the skin-sparing benefits of new RT techniques, most patients develop RD. There is currently no standard treatment to prevent and soothe RD, which is generally managed with emollients, moisturizers, or corticosteroids. We conducted a prospective observational study to evaluate the rate and grade of RD with the application of a cleansing mousse and a non-steroidal emulsion during the adjuvant RT program in patients with breast cancer submitted to surgery. Materials and Methods: A cleansing mousse containing vegetable glycerin (12%), phytoextract of chamomile (0.5%), yarrow phytoextract (0.5%), sweet almond (0.1%), Oenothera oil (0.1%), and rice protein hydrolyzate (0.1%), and an emulsion containing micronized zinc oxide (3.7%), rapeseed phytosterols (1.7%), aloe (0.5%), 18-beta glycyrrhetinic acid (0.5%), alpha bisabolol (0.5%), and zanthalene (0.5%) were offered to breast cancer patients undergoing adjuvant RT to prevent the onset of RD and mitigate its severity. These specific ingredients were selected for their well-known anti-inflammatory, antioxidant, and moisturizing properties. Skin toxicities were recorded photographically and graded according to the RTOG scoring system. Results: From March 2023 to July 2023, a total of 24 patients with a median age of 59 years (range 42–75) were enrolled. Halfway through the RT treatment, 20 patients (83.3%) had G0 skin toxicity, three (12.5%) G1, one (4.2%) G2. None showed G3–G4 toxicity. At the end of RT, seven patients (29.2%) exhibited G0 skin toxicity, 14 (58.3%) G1, two (8.3%) G2, one (4.2%) G3. No patient developed G4 toxicity. Fifteen days after the end of RT, 13 patients (54.2%) had G0 skin toxicity, 10 (41.1%) G1, one (4.2%) G2, with none showing G3–G4 toxicity. Conclusions: Our data suggest that the tested topicals might be an effective option for preventing and alleviating RD. Further prospective randomized studies are needed to confirm our findings.
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来源期刊
Cosmetics
Cosmetics Medicine-Surgery
CiteScore
5.20
自引率
12.10%
发文量
108
审稿时长
8 weeks
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