S. Ramakrishna, Karthik Ageeru, M. Kasala, R. Krupanandan, Karnan Perumal, S. Malleeswaran, Rajanikanth V. Patcha, Joy Varghese, M. S. Reddy, B. Ramachandran, K. Sadasivam
{"title":"首例治疗登革热急性肝衰竭的儿科活体辅助正位肝移植手术","authors":"S. Ramakrishna, Karthik Ageeru, M. Kasala, R. Krupanandan, Karnan Perumal, S. Malleeswaran, Rajanikanth V. Patcha, Joy Varghese, M. S. Reddy, B. Ramachandran, K. Sadasivam","doi":"10.1002/jpr3.12103","DOIUrl":null,"url":null,"abstract":"Dengue fever (DF) is one of the common vector‐borne infections in tropical and subtropical regions worldwide. Liver involvement in DF is common and includes a wide spectrum of clinical and laboratory manifestations ranging from mild transaminitis to acute liver failure (ALF). Dengue ALF has a high mortality rate. The role of liver transplant (LT) in ALF is uncertain mainly due to co‐existing multiorgan dysfunction and the risk of re‐infection as a consequence of post‐transplant immunosuppression. Here, we report the first paediatric living donor auxiliary orthotopic LT in an adolescent boy who developed ALF due to dengue. LT for ALF associated with severe dengue may be an option for patients with isolated liver involvement not responding to standard medical management.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"129 45","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The first paediatric living donor auxiliary orthotopic liver transplant for dengue acute liver failure\",\"authors\":\"S. Ramakrishna, Karthik Ageeru, M. Kasala, R. Krupanandan, Karnan Perumal, S. Malleeswaran, Rajanikanth V. Patcha, Joy Varghese, M. S. Reddy, B. Ramachandran, K. Sadasivam\",\"doi\":\"10.1002/jpr3.12103\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Dengue fever (DF) is one of the common vector‐borne infections in tropical and subtropical regions worldwide. Liver involvement in DF is common and includes a wide spectrum of clinical and laboratory manifestations ranging from mild transaminitis to acute liver failure (ALF). Dengue ALF has a high mortality rate. The role of liver transplant (LT) in ALF is uncertain mainly due to co‐existing multiorgan dysfunction and the risk of re‐infection as a consequence of post‐transplant immunosuppression. Here, we report the first paediatric living donor auxiliary orthotopic LT in an adolescent boy who developed ALF due to dengue. LT for ALF associated with severe dengue may be an option for patients with isolated liver involvement not responding to standard medical management.\",\"PeriodicalId\":501015,\"journal\":{\"name\":\"JPGN reports\",\"volume\":\"129 45\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JPGN reports\",\"FirstCategoryId\":\"0\",\"ListUrlMain\":\"https://doi.org/10.1002/jpr3.12103\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JPGN reports","FirstCategoryId":"0","ListUrlMain":"https://doi.org/10.1002/jpr3.12103","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The first paediatric living donor auxiliary orthotopic liver transplant for dengue acute liver failure
Dengue fever (DF) is one of the common vector‐borne infections in tropical and subtropical regions worldwide. Liver involvement in DF is common and includes a wide spectrum of clinical and laboratory manifestations ranging from mild transaminitis to acute liver failure (ALF). Dengue ALF has a high mortality rate. The role of liver transplant (LT) in ALF is uncertain mainly due to co‐existing multiorgan dysfunction and the risk of re‐infection as a consequence of post‐transplant immunosuppression. Here, we report the first paediatric living donor auxiliary orthotopic LT in an adolescent boy who developed ALF due to dengue. LT for ALF associated with severe dengue may be an option for patients with isolated liver involvement not responding to standard medical management.