首例治疗登革热急性肝衰竭的儿科活体辅助正位肝移植手术

JPGN reports Pub Date : 2024-07-11 DOI:10.1002/jpr3.12103
S. Ramakrishna, Karthik Ageeru, M. Kasala, R. Krupanandan, Karnan Perumal, S. Malleeswaran, Rajanikanth V. Patcha, Joy Varghese, M. S. Reddy, B. Ramachandran, K. Sadasivam
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引用次数: 0

摘要

登革热(DF)是全球热带和亚热带地区常见的病媒传染病之一。登革热的肝脏受累很常见,包括从轻度转氨酶炎到急性肝衰竭(ALF)等多种临床和实验室表现。登革热急性肝衰竭的死亡率很高。肝移植(LT)在 ALF 中的作用尚不确定,这主要是由于同时存在的多器官功能障碍以及移植后免疫抑制导致的再感染风险。在此,我们报告了首例儿科活体辅助正位LT,患者是一名因登革热导致ALF的青少年男孩。对于标准药物治疗无效的孤立性肝脏受累患者,可以选择LT治疗与严重登革热相关的ALF。
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The first paediatric living donor auxiliary orthotopic liver transplant for dengue acute liver failure
Dengue fever (DF) is one of the common vector‐borne infections in tropical and subtropical regions worldwide. Liver involvement in DF is common and includes a wide spectrum of clinical and laboratory manifestations ranging from mild transaminitis to acute liver failure (ALF). Dengue ALF has a high mortality rate. The role of liver transplant (LT) in ALF is uncertain mainly due to co‐existing multiorgan dysfunction and the risk of re‐infection as a consequence of post‐transplant immunosuppression. Here, we report the first paediatric living donor auxiliary orthotopic LT in an adolescent boy who developed ALF due to dengue. LT for ALF associated with severe dengue may be an option for patients with isolated liver involvement not responding to standard medical management.
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