干细胞衍生组织在心脏疾病新疗法中的作用

Yoshinori Yoshida
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引用次数: 0

摘要

对动物实验的限制意味着诱导多能干细胞衍生的人体组织为发现心脏疾病的新型治疗方法提供了一个前景广阔的平台。在心脏疾病新疗法的研发领域,使用小鼠等动物模型存在固有的局限性,这是因为物种之间,特别是人类与实验动物之间存在生理差异。例如,小鼠的心率可超过每分钟 500 次,比人类快得多。
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The role of stem cell-derived tissues in novel treatments for cardiac ailments
Curbs on animal testing mean human tissues derived from induced pluripotent stem cells offer a promising platform in discovering novel treatments for cardiac ailments. In the realm of research and development in novel treatments for cardiac ailments, the use of animal models, such as mice, presents inherent limitations due to physiological discrepancies between species, specifically between humans and experimental animals. For instance, the heart rate in mice can surpass 500 beats per minute, a rate considerably faster than that observed in humans.
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