三维打印的患者专用动态膝关节模拟器

Michele Conconi, N. Sancisi, Reid Backus, Christian Argenti, Albert J Shih
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摘要

目的3D打印设备在不同的临床应用中证明了其功效,有助于实现个性化医疗。本文旨在介绍设计和制作患者专用的人体膝关节动态模拟器的程序。这些模拟器的目的是改善手术效果,研究人体膝关节的运动和负载响应,并通过对患者关节的个性化物理表示,将测试矫形设备的体外实验标准化。根据膝关节的核磁共振成像(MRI),为每名志愿者定义了患者特定的数学关节模型。该模型指导了模拟器的 CAD 设计,然后通过立体光刻印刷实现。通过量化 3D 打印与 CAD 几何图形之间的差异,测试了制造精度。为了评估模拟器的功能,我们通过立体摄影测量系统测量了模拟器的运动,并将其与志愿者的胫骨-股骨自然运动(通过静态核磁共振成像序列进行测量)进行了比较。然而,不同 3D 打印部件的组装导致平均误差达到 0.97 毫米,峰值为 2.33 毫米。尽管如此,模拟器的旋转和平移精度分别约为 5° 和 4 毫米。所提出的方法具有通用性,因此可扩展到其他关节。
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A 3D-printed, dynamic, patient-specific knee simulator
Purpose 3D-printed devices proved their efficacy across different clinical applications, helping personalize medical treatments. This paper aims to present the procedure for the design and production of patient-specific dynamic simulators of the human knee. The scope of these simulators is to improve surgical outcomes, investigate the motion and load response of the human knee and standardize in-vitro experiments for testing orthopedic devices through a personalized physical representation of the patient’s joint. Design/methodology/approach This paper tested the approach on three volunteers. For each, a patient-specific mathematical joint model was defined from an magnetic resonance imaging (MRI) of the knee. The model guided the CAD design of the simulators, which was then realized through stereolithography printing. Manufacturing accuracy was tested by quantifying the differences between 3D-printed and CAD geometry. To assess the simulator functionality, its motion was measured through a stereophotogrammetric system and compared with the natural tibio-femoral motion of the volunteers, measured as a sequence of static MRI. Findings The 3D-printing accuracy was very high, with average differences between ideal and printed parts below ± 0.1 mm. However, the assembly of different 3D-printed parts resulted in a higher average error of 0.97 mm and peak values of 2.33 mm. Despite that, the rotational and translational accuracy of the simulator was about 5° and 4 mm, respectively. Originality/value Although improvements in the production process are needed, the proposed simulators successfully replicated the individual articular behavior. The proposed approach is general and thus extendible to other articulations.
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