尼日利亚阿巴东南部阿比亚州立大学教学医院医护人员的结核菌素皮肤试验反应性

Cornelius Ogu, Chiemela Ebenezar, Obioma Nwaogwugwu, Rita Ogu, Ijeoma Nduka
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摘要

结核病是要根除的传染病之一,目前仍在监测之中。尼日利亚的医院工作人员在诊治病人时很少或根本没有采取预防结核病的措施。 本研究旨在调查尼日利亚大学教学医院医护人员结核菌素皮肤试验阳性反应的发生率。 研究获得了伦理批准和参与者的知情同意。本研究招募了 210 名同意参加研究的人员,其中 185 人参与了研究。结核菌素皮试按照标准操作程序进行。在 P < 0.05 的显著水平下,采用卡方检验对变量进行比较。在接受 BGC 疫苗接种不足 3 年的参与者中,4.8% 未纳入分析。 参与者的平均年龄为(30 ± 8)岁。参与者中有 87 名男性(47%)和 98 名女性(53%)。平均年龄为 21-25 岁。大多数参与者是临床医学学生,占 93 人(50.3%),其次是医生,占 7 人(3.8%)。结核菌素皮肤试验阳性反应率为 29.9%。性别和阳性反应率没有明显差异。未接种过卡介苗的人与研究前≥10 年接种过卡介苗的人在反应性≥10 mm 时存在明显差异。 医护人员可能是潜在的活动性肺结核患者和储库。我们建议对尼日利亚的医护人员进行高灵敏度和特异性的定期结核病筛查、预防性治疗和再接种。
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Tuberculin Skin Test Reactivity among Health Care Workers in the Abia State University Teaching Hospital, Aba South-east Nigeria
Tuberculosis is one of the infections targeted for eradication and is still under surveillance. Hospital workers in Nigeria take little or no precautions against tuberculosis while attending to patients. This research aimed to study the prevalence of the reactivity of positive Tuberculin Skin Tests among healthcare workers in a Nigerian University Teaching Hospital. Ethical approval and informed consent were obtained from the participants. Two hundred and ten consented participants were recruited for this study, while 185 contributed till the end. The Tuberculin Skin Test was conducted following the standard operating procedures. The chi-square test was used to compare the variable at a significant level of P < 0.05. Of those who received a BGC vaccine < 3 years, 4.8% were excluded from the analyses. Mean ± SD of participants’ age was approximately 30 ± 8 years. Participants comprised 87 (47%) males and 98 (53%) females. The modal age group was 21-25 years. Most participants were clinical medical students, 93(50.3%), while doctors, 7 (3.8%), were second to least. The prevalence of positive reactivity to the Tuberculin Skin Test was 29.9%. There was no significant difference observed regarding sexes and positive reactivity. A significant difference was found in reactivity ≥ 10 mm between those who didn’t receive BCG and those who received BCG vaccine ≥ 10 years before the study. Healthcare workers can be potential active TB patients and reservoirs. We recommend highly sensitive and specific periodic TB screening, prophylactic treatment, and re-vaccination of Health Care Workers in Nigeria.
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