评估间质性肺病患者肺纤维化进展的概率以确定进一步的治疗策略

Q4 Medicine Tuberculosis and Lung Diseases Pub Date : 2024-07-04 DOI:10.58838/2075-1230-2024-102-3-34-40

A. A. Lukashevich, O. A. Yudina, L. S. Bogush, E. I. Davidovskaya, M. I. Dyusmikeeva, A. F. Belko

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引用次数: 0

摘要

目的：开发一种评估间质性肺病患者肺纤维化进展概率的方法，以确定进一步的治疗策略。80名间质性肺病患者接受了肺活检，并进行了形态学和免疫组化检测。进行性纤维化组包括 42 名患者。采用二元逻辑回归法建立预后模型。以回归方程的形式建立的统计模型由 3 个参数组成：是否存在间质纤维化的形态模式；CTGF 的表达强度；TGF-β 的表达强度。该数学模型可预测肺间质疾病患者肺纤维化的进展，灵敏度为 83.3%，特异度为 84.2%。

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Assessment of Probability of Pulmonary Fibrosis Progression in Patients with Interstitial Lung Diseases to Determine Further Treatment Tactics

The objective: to develop a method for assessing the probability of progression of pulmonary fibrosis in patients with interstitial lung diseases in order to determine further treatment tactics.Subjects and Methods. 80 patients with interstitial lung diseases underwent lung biopsies with consequent morphological and immunohistochemical tests. The group with progressive fibrosis consisted of 42 patients. The prognostic model was built using the binary logistic regression method.Results. A statistical model was developed in the form of a regression equation consisting of 3 parameters: the presence of a morphological pattern of interstitial fibrosis; intensity of CTGF expression; and intensity of TGF-β expression. This mathematical model makes it possible to predict the progression of pulmonary fibrosis in patients with interstitial lung diseases with 83.3% sensitivity and 84.2% specificity.

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来源期刊

Tuberculosis and Lung Diseases Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： The Journal is aimed for professional development of researchers, doctors, teachers of medical universities and training institutions. The Journal focuses on the presentation of results of research, case studies, issues of differential diagnostics and treatment in the phthisiologist’s practice, national programs on tuberculosis control in the Russian Federation, WHO strategies, discussion of prevention issues to stop transmission of TB/HIVco-infection, and extrapulmonary tuberculosis.