止血喷雾剂用于治疗儿童急性非静脉曲张性上消化道出血:新加坡单中心经验

JPGN reports Pub Date : 2024-07-02 DOI:10.1002/jpr3.12105
Christopher Wen Wei Ho, Lynette Suk‐hui Goh, Lay Queen Ng, Charanya Rajan, V. Logarajah, F. K. Chiou
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引用次数: 0

摘要

止血喷雾剂(HS;Hemospray)是一种粉剂,用于急性上消化道出血(UGIB)患者的内镜止血。事实证明,该药物有效且易于使用。然而,有关其在儿童中疗效和安全性的公开数据仍然很少。我们的目的是描述我们使用 HS 治疗 UGIB 的经验。我们对 2017 年 1 月至 2021 年 12 月期间接受 HS 内镜止血治疗的 0-18 岁患者进行了回顾性审查。我们获得了有关人口统计学、临床表现和合并症的信息。结果为初始止血成功率和再出血率。23 名患者共使用了 25 次 HS。患者年龄中位数为 8 岁(范围:4 个月至 16 岁)。17/25(68%)例患者使用 HS 作为单一疗法。其他治疗方法包括夹子止血和肾上腺素注射。首次止血成功率为 100%,只有 3 名患者(13.0%)出现再次出血。我们的研究结果支持将 HS 用于治疗儿童 UGIB。我们的研究结果支持将 HS 用于儿童 UGIB 的治疗,无论是作为单一疗法还是与其他常规疗法联合使用,HS 凭借其出色的可行性和良好的安全性,有可能成为 UGIB 儿童的首选疗法。
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Haemostatic spray in the management of acute nonvariceal upper gastrointestinal bleeding in children: A single‐centre experience in Singapore
Haemostatic spray (HS; Hemospray) is a powder agent for endoscopic haemostasis in patients with acute upper gastrointestinal bleeding (UGIB). It has been shown to be effective and easy to administer. However, published data on efficacy and safety in children remain scarce. Our aim was to describe our experience with the use of HS in the management of UGIB.A retrospective review was conducted of patients aged 0–18 receiving HS for endoscopic haemostasis from January 2017 to December 2021. Information was obtained on demographics, clinical presentation and comorbidities. Outcomes were successful initial haemostasis and rates of re‐bleeding.A total of 25 applications of HS occurred in 23 patients. The median patient age was 8 years (range: 4 months to 16 years). HS was used in 17/25 (68%) applications as monotherapy. Other treatments employed were clip application and adrenaline injection. One hundred per cent initial haemostasis was achieved with three (13.0%) patients who experienced re‐bleeding. All patients tolerated HS applications with no adverse events.Our finding supports the use of HS in the management of UGIB in children. HS, either as monotherapy or in combination with other conventional therapy, could potentially be the treatment of choice in children with UGIB with its excellent feasibility and good safety profile.
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