Kaya Senegalensis (Desv) A. Juss.的茎皮水提取物和酒精提取物在人类泌尿系统感染中的抗氧化和抗菌活性

Kamagaté Tidiane, Gboko Abiba Ouattara, K. Dosso, Touré Abdoulaye, Boni Ahoussi Pascal, Kablan Ahmont Landry Claude
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摘要

泌尿系统感染是当今的一个公共卫生问题,致病菌对普通抗菌药的抗药性越来越强。使用植物或植物产品来对抗这些病症被认为是一种不错的选择。本研究的目的是确定 70% 的卡亚塞内加尔茎皮水提取物和水乙醇提取物的体外抗氧化能力和抗菌活性,这些提取物对大肠杆菌和葡萄球菌属泌尿系统感染的临床菌株以及两种参考菌株具有抗菌活性。抗氧化活性是通过 ABTS 自由基阳离子捕获法(以三氯氧磷为参照物)证明的。采用穆勒欣顿琼脂冲孔法和液体稀释法分别测定了菌株对两种提取物的敏感性和抗菌参数,即最低抑菌浓度(MIC)和最低杀菌浓度(MBC)。两种提取物的抗氧化能力都在 50 μmol TE/L 左右。水提取物的 MIC 从 6.25 毫克/毫升到 12.5 毫克/毫升不等,水乙醇提取物的 MIC 从 6.25 毫克/毫升到 25 毫克/毫升不等。所有菌株的 MBC 与 MIC 相同,表明这两种提取物对除金黄色葡萄球菌参照菌株以外的菌株都有杀菌能力。这些结果表明,K. senegalensis 可以作为防治泌尿系统感染的一种替代药物。
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Antioxidant and Antibacterial Activity of Aqueous and Alcoholic Stem Bark Extracts of Kaya Senegalensis (Desv) A. Juss., in Human Urinary Infections
Urinary infections constitute a public health problem today and the responsible germs increasingly express their strong resistance to common antimicrobials. The use of plants or plant products in fight against these pathologies are considered to be a goood alternative. The objective of this study is to determine in vitro antioxidant power and antibacterial activity of aqueous and hydro-ethanolic extracts 70% of stem bark of Kaya senegalensis (Meliaceae) on clinical strains of E.coli and Staphylococcus spp. urinary infections and on two reference strains. The antioxidant activity was demonstrated by the ABTS radical cation trapping method using trolox as a reference. Sensitivity of strains to the two extracts and antibacterial parameters which are minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined respectively by punch well method in Mueller Hinton agar and liquid dilution method. Both extracts expressed a strong antioxidant power around 50 μmol TE/L of extract. The MICs varied from 6.25 mg/mL to 12.5 mg/mL for aqueous extract and from 6.25 mg/mL to 25 mg/mL for hydro-ethanolic extract. For all the strains MBC was identical to the MIC indicating that the two extracts have bactericidal power on the strains excluding the reference strain of S.aureus. These results suggest that K. senegalensis could be an alternative in the fight against urinary infections.
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