柠檬香膏对大鼠甲状腺功能亢进的改善作用

Ragaa Salah Kawara, Fatma Moawed, Hussein Abd Elmaksoud, Yakout Elsenosi, Omayma R Abo-Zaid
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摘要

关键词 香茅具有多种治疗效果,包括抗菌活性(抗寄生虫、抗菌、抗病毒、抗真菌等)。多项研究表明,柠檬香膏通过其化学成分(包括大量类黄酮、迷迭香酸、没食子酸和酚类成分)具有很高的抗氧化活性。本研究旨在评估柠檬香膏提取物对艾曲霉素诱导的甲状腺机能亢进症的治疗效果。给大鼠注射甲状腺素(100 μg/kg/天),连续14天,诱发甲亢。在注射甲状腺素的第二周开始,给甲亢大鼠口服香茅提取物(75 毫克/千克/天),并持续一周。使用商业试剂盒测量促甲状腺激素(TSH)、T3、T4 和氧化生物标志物(NO 和 CAT)的水平。采集甲状腺标本进行组织病理学检查。此外,与甲状腺功能亢进组相比,柠檬香脂提取物通过抑制 NO 和增加 CAT 缓解了炎症反应。因此,这些结果可能会加强香茅提取物在甲亢大鼠模型中的保护作用。
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Ameliorative effect of lemon balm on eltroxin induced-hyperthyroidism in rats
Keywords Lemon balm has many therapeutic effects including antimicrobial activity (anti-parasitic, antibacterial, antiviral, antifungal, etc.). Various studies have shown that Lemon balm possesses a high amount of antioxidant activity through its chemical components including high amount of flavonoids, rosmaric acid, gallic acid and phenolic contents. This study was designed to evaluate the therapeutic effect of Lemon balm extract against hyperthyroidism induced by Eltroxin. Hyperthyroidism was induced by injecting rats with Eltroxin (100 μg/kg/ day) for 14 days. The hyperthyroid rats were orally treated with Lemon balm extract (75 mg/kg/day) at the beginning of the second week of the Eltroxin injection and continued for another week. The levels of TSH , T3 ,T4 and oxidative biomarkers (NO and CAT ) were measured using commercial kits. Thyroid specimens were taken for histopathological examination. Lemon balm extract reversed the effect of Eltroxin on rats and attenuated the thyroid hormones Additionally, Lemon balm extract alleviated the inflammatory response by suppressing the NO and increasing CAT when compared to hyperthyroid group. Accordingly, these results might strengthen the protective effect of Lemon balm extract in a rat model of hyperthyroidism.
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