野生分子在哪里?信号分子空间分布工程学

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Current Opinion in Biomedical Engineering Pub Date : 2024-07-08 DOI:10.1016/j.cobme.2024.100551
{"title":"野生分子在哪里?信号分子空间分布工程学","authors":"","doi":"10.1016/j.cobme.2024.100551","DOIUrl":null,"url":null,"abstract":"<div><p>The spatial distribution of the signaling molecules that mediate cell–cell communication and pattern formation is an important consideration for natural and engineered multicellular systems.</p><p>Signaling molecule concentration profiles directly impact cell response profiles, and various experimental techniques can be utilized to modulate these spatial distributions. Current strategies focused on physically or chemically modifying the extracellular space to affect signal distribution include performing experiments in microfluidic devices with dynamic user-controlled inputs and flow rates or adjusting the mesh sizes and protein binding affinities of extracellular matrix-mimicking hydrogels. Recent advances in synthetic biology have paved the way for new approaches that involve directly engineering the signaling molecules, their interactors, and their downstream effectors for fully orthogonal communication platforms.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Where the wild molecules are: Engineering the spatial distribution of signaling molecules\",\"authors\":\"\",\"doi\":\"10.1016/j.cobme.2024.100551\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The spatial distribution of the signaling molecules that mediate cell–cell communication and pattern formation is an important consideration for natural and engineered multicellular systems.</p><p>Signaling molecule concentration profiles directly impact cell response profiles, and various experimental techniques can be utilized to modulate these spatial distributions. Current strategies focused on physically or chemically modifying the extracellular space to affect signal distribution include performing experiments in microfluidic devices with dynamic user-controlled inputs and flow rates or adjusting the mesh sizes and protein binding affinities of extracellular matrix-mimicking hydrogels. Recent advances in synthetic biology have paved the way for new approaches that involve directly engineering the signaling molecules, their interactors, and their downstream effectors for fully orthogonal communication platforms.</p></div>\",\"PeriodicalId\":36748,\"journal\":{\"name\":\"Current Opinion in Biomedical Engineering\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Biomedical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S246845112400031X\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S246845112400031X","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

摘要

信号分子的浓度分布直接影响细胞的反应曲线,可以利用各种实验技术来调节这些空间分布。目前的策略侧重于通过物理或化学方法改变细胞外基质空间以影响信号分布,包括在微流控装置中进行实验,用户可动态控制输入和流速,或调整细胞外基质模拟水凝胶的网孔大小和蛋白质结合亲和力。合成生物学的最新进展为新方法铺平了道路,这些新方法涉及直接设计信号分子、其相互作用者及其下游效应器,以实现完全正交的通信平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Where the wild molecules are: Engineering the spatial distribution of signaling molecules

The spatial distribution of the signaling molecules that mediate cell–cell communication and pattern formation is an important consideration for natural and engineered multicellular systems.

Signaling molecule concentration profiles directly impact cell response profiles, and various experimental techniques can be utilized to modulate these spatial distributions. Current strategies focused on physically or chemically modifying the extracellular space to affect signal distribution include performing experiments in microfluidic devices with dynamic user-controlled inputs and flow rates or adjusting the mesh sizes and protein binding affinities of extracellular matrix-mimicking hydrogels. Recent advances in synthetic biology have paved the way for new approaches that involve directly engineering the signaling molecules, their interactors, and their downstream effectors for fully orthogonal communication platforms.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
期刊最新文献
Editorial Board Contents Computational modeling of autonomic nerve stimulation: Vagus et al. Synthetically programming natural cell–cell communication pathways for tissue engineering What can protein circuit design learn from DNA nanotechnology?
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1