野生分子在哪里?信号分子空间分布工程学

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Current Opinion in Biomedical Engineering Pub Date : 2024-07-08 DOI:10.1016/j.cobme.2024.100551
Xinwen Zhu, Erin Neu, Wilson W. Wong
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引用次数: 0

摘要

信号分子的浓度分布直接影响细胞的反应曲线,可以利用各种实验技术来调节这些空间分布。目前的策略侧重于通过物理或化学方法改变细胞外基质空间以影响信号分布,包括在微流控装置中进行实验,用户可动态控制输入和流速,或调整细胞外基质模拟水凝胶的网孔大小和蛋白质结合亲和力。合成生物学的最新进展为新方法铺平了道路,这些新方法涉及直接设计信号分子、其相互作用者及其下游效应器,以实现完全正交的通信平台。
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Where the wild molecules are: Engineering the spatial distribution of signaling molecules

The spatial distribution of the signaling molecules that mediate cell–cell communication and pattern formation is an important consideration for natural and engineered multicellular systems.

Signaling molecule concentration profiles directly impact cell response profiles, and various experimental techniques can be utilized to modulate these spatial distributions. Current strategies focused on physically or chemically modifying the extracellular space to affect signal distribution include performing experiments in microfluidic devices with dynamic user-controlled inputs and flow rates or adjusting the mesh sizes and protein binding affinities of extracellular matrix-mimicking hydrogels. Recent advances in synthetic biology have paved the way for new approaches that involve directly engineering the signaling molecules, their interactors, and their downstream effectors for fully orthogonal communication platforms.

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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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