睡眠中的脑血流量:系统回顾与元分析

IF 11.2 1区 医学 Q1 CLINICAL NEUROLOGY Sleep Medicine Reviews Pub Date : 2024-07-14 DOI:10.1016/j.smrv.2024.101977
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引用次数: 0

摘要

睡眠在生理学中发挥着至关重要的作用,它能让大脑和身体自我恢复。尽管睡眠起着至关重要的作用,但我们对睡眠中人脑基本过程的了解仍然有限。睡眠包括几个不同的阶段,其深度和时间组成各不相同。脑血流量(CBF)为大脑输送必需的营养和氧气,在这些睡眠阶段中,脑部各区域的脑血流量各不相同,反映了神经元功能和调节的变化。我们收录、评估并总结了所有 38 项已发表的有关健康人 CBF 的睡眠研究,这些健康人没有或仅有轻微(24 小时)睡眠不足。我们的主要发现是,CBF 随睡眠阶段和深度而变化,通常在 NREM 睡眠中最低,而在 REM 睡眠中最高。这些变化似乎源于特定睡眠阶段的大脑区域活动,这些活动具有特定的功能,如意识和情绪处理的改变。
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Cerebral blood flow in sleep: A systematic review and meta-analysis

Sleep plays an essential role in physiology, allowing the brain and body to restore itself. Despite its critical role, our understanding of the underlying processes in the sleeping human brain is still limited. Sleep comprises several distinct stages with varying depths and temporal compositions. Cerebral blood flow (CBF), which delivers essential nutrients and oxygen to the brain, varies across brain regions throughout these sleep stages, reflecting changes in neuronal function and regulation.

This systematic review and meta-analysis assesses global and regional CBF across sleep stages. We included, appraised, and summarized all 38 published sleep studies on CBF in healthy humans that were not or only slightly (<24 h) sleep deprived. Our main findings are that CBF varies with sleep stage and depth, being generally lowest in NREM sleep and highest in REM sleep. These changes appear to stem from sleep stage-specific regional brain activities that serve particular functions, such as alterations in consciousness and emotional processing.

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来源期刊
Sleep Medicine Reviews
Sleep Medicine Reviews 医学-临床神经学
CiteScore
20.10
自引率
3.80%
发文量
107
期刊介绍: Sleep Medicine Reviews offers global coverage of sleep disorders, exploring their origins, diagnosis, treatment, and implications for related conditions at both individual and public health levels. Articles comprehensively review clinical information from peer-reviewed journals across various disciplines in sleep medicine, encompassing pulmonology, psychiatry, psychology, physiology, otolaryngology, pediatrics, geriatrics, cardiology, dentistry, nursing, neurology, and general medicine. The journal features narrative reviews, systematic reviews, and editorials addressing areas of controversy, debate, and future research within the field.
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