治疗肺结核强化期和晚期时γ干扰素水平的差异

Jurnal Biosains Pascasarjana Pub Date : 2024-07-01 DOI:10.20473/jbp.v26i1.2024.72-76

Rachmad Bayu Kuncara, SY. Didik Widiyanto, Ririh Jatmi Wikandari, Wiwit Sulistyasmi

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引用次数: 0

摘要

结核病（TB）是由结核分枝杆菌复合体（MTBC）引起的一种慢性传染病。为活动性肺结核患者提供的抗结核药物包括 3 或 4 种复方制剂。结核病治疗分为强化期治疗（2 周）和持续期治疗（16 周/4 个月）。γ干扰素（IFN δ³）是一种属于细胞因子家族的蛋白质，通过细胞介导的免疫机制在消除 MTB 细菌方面发挥作用。本研究旨在分析结核病强化治疗阶段和晚期治疗阶段γ干扰素水平的差异。该研究方法是一项横断面设计的分析性观察研究（横断面研究）。采用的研究设计是随机后测对照组设计。数据采用 Kruskal Wallis 检验进行分析，统计检验结果的 P 值为 0.033（> 0.05），这意味着结核病强化治疗阶段和晚期治疗阶段的 IFN δ³ 水平存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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DIFFERENCES IN INTERFERON GAMMA LEVELS IN TREATMENT OF TUBERCULOSIS IN INTENSIVE PHASE AND ADVANCED PHASE

Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis complex (MTBC). Anti-tuberculosis drugs given to active TB sufferers consist of 3 or 4 combinations. Tuberculosis treatment is divided into intensive phase treatment (2 weeks) and continuation phase (16 weeks / 4 months). Interferon gamma (IFN Î³) is a protein belonging to the cytokine family which plays a role in eliminating MTB bacteria through a cell-mediated immunity mechanism. The aim of this study was to analyze differences in gamma interferon levels in the intensive phase and advanced phase of tuberculosis treatment. This research method is an analytical observational study with a cross-sectional design (cross sectional study). The research design used was a randomized post test only control group design. Data were analyzed using the Kruskal Wallis test with statistical test results obtained with a p value of 0.033 (> 0.05), meaning there was a difference in IFN Î³ levels in the intensive phase and advanced phase of tuberculosis treatment.

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Jurnal Biosains Pascasarjana

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