O-162 近海石油工人患癌症的风险

Karina Undem, K. Nordby, J. Stenehjem, Jorunn Kirkeleit, I. Mehlum, Rachel L Hasting
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摘要

近海石油工人有可能接触到已知和可疑的致癌物质。我们的目标是评估挪威登记在册的近海工人队列中的癌症发病率。 该队列由1983年受雇于近海作业的6600名16-53岁男性组成,并与挪威癌症登记处建立了联系,进行1984-2020年的跟踪调查。研究以普通劳动人口为参照组,估算了所有癌症和94种癌症的日历期和年龄标准化发病率(SIR)及95%置信区间(CI)。 研究显示,所有癌症的年龄发病率比为 1.17(95% 置信区间:1.11-1.23)。在肾癌(SIR:1.35,95% CI:1.05-1.71)、膀胱癌(1.41,1.14-1.74)、喉癌(1.92,1.20-2.90)、肺癌(1.26,1.20-2.9090)、肺(1.26,1.09-1.46)、间皮瘤(1.90,1.01-3.25)和食道(所有类型(1.66,1.13-2.36)和腺癌(1.80,1.07-2.85))。然而,急性髓性白血病(1.04,0.47-1.97)或多发性骨髓瘤(1.15,0.78-1.63)则没有发现超额风险。 除了没有发现淋巴肿瘤的超高风险和肾癌的超高风险这一新颖发现外,研究结果还证实了现有的研究,并强调了离岸工人面临风险增加的几种癌症类型。现有数据无法对特定致癌物质进行风险评估,也无法控制生活方式等潜在混杂因素。 在这项以登记为基础的研究中,1983 年参加工作的近海工人患某些癌症的风险比普通工人高。对接触时间长短、接触期和工作类型的进一步调查可能会产生更多有价值的见解。
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O-162 RISK OF CANCER AMONG OFFSHORE PETROLEUM WORKERS
Petroleum workers offshore have a potential for exposure to known and suspected carcinogens. We aimed to assess cancer incidence in a Norwegian register-based cohort of offshore workers. The cohort comprised 6600 men, aged 16-53, employed in offshore work in 1983, and was linked to the Cancer Registry of Norway for follow-up 1984–2020. Calendar period and age-standardised incidence ratios (SIRs) with 95% confidence intervals (CI) were estimated for all cancers combined and for 94 cancer sites using the general working population as the reference group. For all cancers combined, the study showed a SIR of 1.17 (95% CI: 1.11-1.23). Elevated risks were observed for cancer of the kidney (SIR: 1.35, 95% CI: 1.05-1.71), bladder (1.41, 1.14-1.74), larynx (1.92, 1.20-2.90), lung (1.26, 1.09-1.46), mesothelioma (1.90, 1.01-3.25) and oesophagus (all types (1.66, 1.13-2.36) and adenocarcinoma (1.80, 1.07-2.85)). However, no excess risk was observed for acute myeloid leukaemia (1.04, 0.47-1.97) or multiple myeloma (1.15, 0.78-1.63). Apart from the absence of excess risk of lymphohematological neoplasms and the novel finding of excess risk of kidney cancer, the findings corroborate existing research and underscore several cancer types for which offshore workers face increased risks. The available data did not allow for risk assessment of specific carcinogens or control of potential confounding factors such as lifestyle. In this register-based study, offshore workers active in 1983 had increased risk of certain cancers compared to the general working population. Further investigation into length of exposure, period of exposure and job type could yield further valuable insights.
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