调查药品和膳食补充剂的发光信号,用于紧急剂量测定

IF 1.6 3区 物理与天体物理 Q2 NUCLEAR SCIENCE & TECHNOLOGY Radiation Measurements Pub Date : 2024-07-05 DOI:10.1016/j.radmeas.2024.107225
Anna Mrozik , Dorota Kuźnik , Paweł Bilski , Michael Discher
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引用次数: 0

摘要

本研究利用光激发发光(OSL)现象,探讨了将含有镁、钙或钾的膳食补充剂和药品用于紧急剂量测定的可能性。使用不同的激发波长进行了信号测量,发现蓝光激发最有效。与之前测量的其他应急探测器相比,半数以上的样品显示出可测的 OSL 信号和相对较高的辐射灵敏度。此外,样品普遍表现出线性剂量反应。研究了造成样品零剂量信号较高的可能原因:机械加工和紫外光激发。由于观察到灵敏度存在差异,因此在测量过程中使用了测试剂量协议。此外,研究还表明,在照射后 24 小时内,OSL 信号强度会明显降低,这表明有必要进行衰减校正。最后,还进行了剂量恢复测试,以评估现实条件下的材料和测试剂量方案。研究结果表明,由于药物和膳食补充剂具有剂量学特性且易于获取,因此在发生辐射紧急情况时有可能使用它们。
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Investigating luminescence signals of pharmaceuticals and dietary supplements for emergency dosimetry

This study investigates the potential use of dietary supplements and pharmaceuticals containing magnesium, calcium or potassium for emergency dosimetry applications using the phenomenon of optically stimulated luminescence (OSL). Signal measurements were carried out using different stimulation wavelengths, and blue light stimulation was found to be the most efficient. More than half of the samples exhibited a measurable OSL signal and relatively high radiation sensitivity compared to other previously measured emergency detectors. Moreover, samples generally demonstrated a linear dose response. Possible causes of their high zero-dose signal were investigated: mechanical processing and UV light excitation. As variability in sensitivity was observed, the test-dose protocol was used during measurements. Furthermore, the study showed a significant loss of OSL signal intensity within 24 h after irradiation, which suggests the necessity for a fading correction. Finally, a dose recovery test was performed to evaluate the materials and the test-dose protocol under realistic conditions. The findings indicate the potential for using pharmaceuticals and dietary supplements in the event of a radiation emergency due to their dosimetric properties and ease of obtaining.

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来源期刊
Radiation Measurements
Radiation Measurements 工程技术-核科学技术
CiteScore
4.10
自引率
20.00%
发文量
116
审稿时长
48 days
期刊介绍: The journal seeks to publish papers that present advances in the following areas: spontaneous and stimulated luminescence (including scintillating materials, thermoluminescence, and optically stimulated luminescence); electron spin resonance of natural and synthetic materials; the physics, design and performance of radiation measurements (including computational modelling such as electronic transport simulations); the novel basic aspects of radiation measurement in medical physics. Studies of energy-transfer phenomena, track physics and microdosimetry are also of interest to the journal. Applications relevant to the journal, particularly where they present novel detection techniques, novel analytical approaches or novel materials, include: personal dosimetry (including dosimetric quantities, active/electronic and passive monitoring techniques for photon, neutron and charged-particle exposures); environmental dosimetry (including methodological advances and predictive models related to radon, but generally excluding local survey results of radon where the main aim is to establish the radiation risk to populations); cosmic and high-energy radiation measurements (including dosimetry, space radiation effects, and single event upsets); dosimetry-based archaeological and Quaternary dating; dosimetry-based approaches to thermochronometry; accident and retrospective dosimetry (including activation detectors), and dosimetry and measurements related to medical applications.
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