E. A. Danilova, N. S. Osinskaya, B. I. Kurbanov, S. K. Khudoynazarov, S. H. Khusniddinova
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Development of a Neutron Activation Analysis Method for Studying the Elemental Composition of Atherosclerotic Plaques
Atherosclerosis is one of the most important problems of modern medicine. It involves changes in the structure and inner lining of the arteries. Studying chemical elements directly in vascular tissues allows understanding the mechanisms of evolvement of cardiovascular diseases, in particular, atherosclerosis. This study is aimed at developing the neutron activation technique for the analysis of atherosclerotic plaques formed at various stages of the atherosclerosis and studying their composition. The content of 13 elements in lipid, fibrous, ulcerated, and calcific plaques was determined using the developed method. It was established that upon evolving atherosclerosis, the content of a number of essential elements changes, the content of calcium, strontium, selenium, zinc and iron increases, and the bromine content decreases. Also, it was suggested that iron plays a role in the evolution of atherosclerotic vascular lesions.
期刊介绍：
Radiochemistry is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.
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