{"title":"3H]透明质酸与羟基磷灰石的吸附相互作用特征","authors":"G. A. Badun, A. V. Severin, E. A. Zaitseva","doi":"10.1134/S106636222403010X","DOIUrl":null,"url":null,"abstract":"<p> [<sup>3</sup>H]Hyaluronic acid with a molecular weight of 2.37 MDa and a specific radioactivity of 35 GBq/g was obtained using the tritium thermal activation method. Tritium labeled hyaluronic acid (HA) with a molecular weight of 2.37, 0.20, and 0.10 MDa were used to study their adsorption on hydroxyapatite (HAP) in two textural modifications: aqueous suspension and powder. Differences in adsorption kinetics and adsorption isotherms were observed due to variations in the interaction between polysaccharide molecules and the sorbent forms under consideration. The adsorption isotherms of HA on HAP were proven linear. It is shown that strong HA–HAP complexes are formed, and no desorption of HA into water and 0.9% NaCl solution were detected in 2 days.</p>","PeriodicalId":747,"journal":{"name":"Radiochemistry","volume":"66 3","pages":"364 - 371"},"PeriodicalIF":0.9000,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Features of the Sorption Interaction of [3H]Hyaluronic Acid with Hydroxyapatite\",\"authors\":\"G. A. Badun, A. V. Severin, E. A. Zaitseva\",\"doi\":\"10.1134/S106636222403010X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p> [<sup>3</sup>H]Hyaluronic acid with a molecular weight of 2.37 MDa and a specific radioactivity of 35 GBq/g was obtained using the tritium thermal activation method. Tritium labeled hyaluronic acid (HA) with a molecular weight of 2.37, 0.20, and 0.10 MDa were used to study their adsorption on hydroxyapatite (HAP) in two textural modifications: aqueous suspension and powder. Differences in adsorption kinetics and adsorption isotherms were observed due to variations in the interaction between polysaccharide molecules and the sorbent forms under consideration. The adsorption isotherms of HA on HAP were proven linear. It is shown that strong HA–HAP complexes are formed, and no desorption of HA into water and 0.9% NaCl solution were detected in 2 days.</p>\",\"PeriodicalId\":747,\"journal\":{\"name\":\"Radiochemistry\",\"volume\":\"66 3\",\"pages\":\"364 - 371\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2024-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S106636222403010X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiochemistry","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1134/S106636222403010X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Features of the Sorption Interaction of [3H]Hyaluronic Acid with Hydroxyapatite
[3H]Hyaluronic acid with a molecular weight of 2.37 MDa and a specific radioactivity of 35 GBq/g was obtained using the tritium thermal activation method. Tritium labeled hyaluronic acid (HA) with a molecular weight of 2.37, 0.20, and 0.10 MDa were used to study their adsorption on hydroxyapatite (HAP) in two textural modifications: aqueous suspension and powder. Differences in adsorption kinetics and adsorption isotherms were observed due to variations in the interaction between polysaccharide molecules and the sorbent forms under consideration. The adsorption isotherms of HA on HAP were proven linear. It is shown that strong HA–HAP complexes are formed, and no desorption of HA into water and 0.9% NaCl solution were detected in 2 days.
期刊介绍：
Radiochemistry is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.
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