{"title":"维生素 D 补充剂对干眼症的疗效:系统回顾与荟萃分析。","authors":"","doi":"10.1016/j.clae.2024.102169","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>Vitamin D (VD) is a vitamin with anti-inflammatory and immunomodulatory effects. Several studies have shown that VD deficiency is associated with the incidence and severity of dry eye disease (DED) in humans. This <em>meta</em>-analysis compared signs and symptoms in patients with DED before and after VD supplementation.</p></div><div><h3>Methods</h3><p>Ten databases (PubMed, Cochrane, Web of science, Ovid, Embase, Scopus, CNKI, CSTJ, Wanfang, Sinomed) and four clinical trials registry websites (ISRCTN, CT, ICTRP, ICH GCP) were searched for studies on the efficacy of VD supplement in patients with DED that were published up to 2023 January. A total of 8 studies with 439 cases were included. Two reviewers independently assessed the quality of the literature and extracted data to calculate standard mean differences (SMD) for the Schirmer's test (SH test), tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS, Oxford Scale, 0–5), lid hyperemia, ocular surface disease index (OSDI), and visual analogue pain scale (VAS).</p></div><div><h3>Results</h3><p>The analysis showed that VD supplementation improved tear production (SMD 1.43, 95% CI 0.81, 2.05, p = 0.000) and tear film stability (SMD 1.19, 95% CI 0.83, 1.55, p = 0.000) and reduced lid hyperemia (SMD −0.71, 95% CI −1.09, −0.32, p = 0.000) and OSDI (SMD −1.10, 95% CI −1.45, −0.74, p = 0.000), which is effective in alleviating the signs and symptoms of DED.</p></div><div><h3>Conclusions</h3><p>VD supplementation could be an adjuvant treatment to alleviate the signs and symptoms of dry eye in the future. However, further studies regarding its most appropriate administration and dosage need to be conducted.</p></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1367048424000614/pdfft?md5=1d21bf2840d78c8c9c8ac7a6dacf745d&pid=1-s2.0-S1367048424000614-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The efficacy of vitamin D supplementation in dry eye disease: A systematic review and meta-analysis\",\"authors\":\"\",\"doi\":\"10.1016/j.clae.2024.102169\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>Vitamin D (VD) is a vitamin with anti-inflammatory and immunomodulatory effects. Several studies have shown that VD deficiency is associated with the incidence and severity of dry eye disease (DED) in humans. This <em>meta</em>-analysis compared signs and symptoms in patients with DED before and after VD supplementation.</p></div><div><h3>Methods</h3><p>Ten databases (PubMed, Cochrane, Web of science, Ovid, Embase, Scopus, CNKI, CSTJ, Wanfang, Sinomed) and four clinical trials registry websites (ISRCTN, CT, ICTRP, ICH GCP) were searched for studies on the efficacy of VD supplement in patients with DED that were published up to 2023 January. A total of 8 studies with 439 cases were included. Two reviewers independently assessed the quality of the literature and extracted data to calculate standard mean differences (SMD) for the Schirmer's test (SH test), tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS, Oxford Scale, 0–5), lid hyperemia, ocular surface disease index (OSDI), and visual analogue pain scale (VAS).</p></div><div><h3>Results</h3><p>The analysis showed that VD supplementation improved tear production (SMD 1.43, 95% CI 0.81, 2.05, p = 0.000) and tear film stability (SMD 1.19, 95% CI 0.83, 1.55, p = 0.000) and reduced lid hyperemia (SMD −0.71, 95% CI −1.09, −0.32, p = 0.000) and OSDI (SMD −1.10, 95% CI −1.45, −0.74, p = 0.000), which is effective in alleviating the signs and symptoms of DED.</p></div><div><h3>Conclusions</h3><p>VD supplementation could be an adjuvant treatment to alleviate the signs and symptoms of dry eye in the future. However, further studies regarding its most appropriate administration and dosage need to be conducted.</p></div>\",\"PeriodicalId\":49087,\"journal\":{\"name\":\"Contact Lens & Anterior Eye\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1367048424000614/pdfft?md5=1d21bf2840d78c8c9c8ac7a6dacf745d&pid=1-s2.0-S1367048424000614-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Contact Lens & Anterior Eye\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1367048424000614\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contact Lens & Anterior Eye","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1367048424000614","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的:维生素 D(VD)是一种具有抗炎和免疫调节作用的维生素。多项研究表明,维生素 D 缺乏与人类干眼症(DED)的发病率和严重程度有关。这项荟萃分析比较了补充 VD 前后 DED 患者的体征和症状:检索了10个数据库(PubMed、Cochrane、Web of science、Ovid、Embase、Scopus、CNKI、CSTJ、Wanfang、Sinomed)和4个临床试验注册网站(ISRCTN、CT、ICTRP、ICH GCP)中截至2023年1月发表的有关补充VD对DED患者疗效的研究。共纳入 8 项研究,439 个病例。两名审稿人独立评估文献质量,并提取数据计算施尔默试验(SH试验)、泪膜破裂时间(TBUT)、角膜荧光素染色评分(CFSS,牛津量表,0-5分)、睑充血、眼表疾病指数(OSDI)和视觉模拟疼痛量表(VAS)的标准均差(SMD):分析表明,补充 VD 可提高泪液分泌量(SMD 1.43,95% CI 0.81,2.05,p = 0.000)和泪膜稳定性(SMD 1.19,95% CI 0.83,1.55,p = 0.000)和降低睑过度充血(SMD -0.71,95% CI -1.09, -0.32,p = 0.000)和OSDI(SMD -1.10,95% CI -1.45, -0.74,p = 0.000),从而有效缓解DED的体征和症状:结论:补充 VD 可作为一种辅助治疗手段,在未来缓解干眼症的症状和体征。结论:补充 VD 可作为一种辅助治疗手段,在未来缓解干眼症的症状和体征,但其最合适的给药方法和剂量仍有待进一步研究。
The efficacy of vitamin D supplementation in dry eye disease: A systematic review and meta-analysis
Purpose
Vitamin D (VD) is a vitamin with anti-inflammatory and immunomodulatory effects. Several studies have shown that VD deficiency is associated with the incidence and severity of dry eye disease (DED) in humans. This meta-analysis compared signs and symptoms in patients with DED before and after VD supplementation.
Methods
Ten databases (PubMed, Cochrane, Web of science, Ovid, Embase, Scopus, CNKI, CSTJ, Wanfang, Sinomed) and four clinical trials registry websites (ISRCTN, CT, ICTRP, ICH GCP) were searched for studies on the efficacy of VD supplement in patients with DED that were published up to 2023 January. A total of 8 studies with 439 cases were included. Two reviewers independently assessed the quality of the literature and extracted data to calculate standard mean differences (SMD) for the Schirmer's test (SH test), tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS, Oxford Scale, 0–5), lid hyperemia, ocular surface disease index (OSDI), and visual analogue pain scale (VAS).
Results
The analysis showed that VD supplementation improved tear production (SMD 1.43, 95% CI 0.81, 2.05, p = 0.000) and tear film stability (SMD 1.19, 95% CI 0.83, 1.55, p = 0.000) and reduced lid hyperemia (SMD −0.71, 95% CI −1.09, −0.32, p = 0.000) and OSDI (SMD −1.10, 95% CI −1.45, −0.74, p = 0.000), which is effective in alleviating the signs and symptoms of DED.
Conclusions
VD supplementation could be an adjuvant treatment to alleviate the signs and symptoms of dry eye in the future. However, further studies regarding its most appropriate administration and dosage need to be conducted.
期刊介绍:
Contact Lens & Anterior Eye is a research-based journal covering all aspects of contact lens theory and practice, including original articles on invention and innovations, as well as the regular features of: Case Reports; Literary Reviews; Editorials; Instrumentation and Techniques and Dates of Professional Meetings.