{"title":"小鼠吗啡溶液对metkephhamid (LY127623)的交叉耐受。","authors":"J D Leander","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effects of morphine and metkephamid were determined on the writhing test in drug-naive mice and mice that had been exposed to morphine solutions as their sole fluid source for a 5- or 7-day period. The average dose of morphine consumed was 435 mg/kg, using either 0.5 mg/ml solution for 7 days or a 1 mg/ml solution for 5 days. The ingestion of these morphine solutions produced a marked tolerance to the analgesic effects of morphine and cross-tolerance to the analgesic effects of metkephamid.</p>","PeriodicalId":7671,"journal":{"name":"Alcohol and drug research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cross-tolerance to metkephamid (LY127623) produced by morphine solution ingestion by mice.\",\"authors\":\"J D Leander\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effects of morphine and metkephamid were determined on the writhing test in drug-naive mice and mice that had been exposed to morphine solutions as their sole fluid source for a 5- or 7-day period. The average dose of morphine consumed was 435 mg/kg, using either 0.5 mg/ml solution for 7 days or a 1 mg/ml solution for 5 days. The ingestion of these morphine solutions produced a marked tolerance to the analgesic effects of morphine and cross-tolerance to the analgesic effects of metkephamid.</p>\",\"PeriodicalId\":7671,\"journal\":{\"name\":\"Alcohol and drug research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alcohol and drug research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alcohol and drug research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cross-tolerance to metkephamid (LY127623) produced by morphine solution ingestion by mice.
The effects of morphine and metkephamid were determined on the writhing test in drug-naive mice and mice that had been exposed to morphine solutions as their sole fluid source for a 5- or 7-day period. The average dose of morphine consumed was 435 mg/kg, using either 0.5 mg/ml solution for 7 days or a 1 mg/ml solution for 5 days. The ingestion of these morphine solutions produced a marked tolerance to the analgesic effects of morphine and cross-tolerance to the analgesic effects of metkephamid.
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