Wook Kim, Jeong Ah Hwang, Ji Hye Min, Sunyoung Lee, Ji Eun Lee, Jaeseung Shin, Woo Kyoung Jeong
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The conventional LSM was determined by manually drawing ROIs on the elastogram within the 95% confidence region, staying 1 cm within the liver capsule and excluding large hilar vessels, the gallbladder, hepatic lesions, and artifacts. In addition, the modified LSM was determined by excluding intrahepatic segmental vessels. LSMs obtained by the two methods were compared with paired sample signed-rank test. Diagnostic performance for advanced fibrosis was calculated and compared using McNemar's test and Delong's test. The stage of hepatic fibrosis was assessed using surgical specimens by the METAVIR system.</p><p><strong>Results: </strong>The modified LSM was larger than the conventional LSM (2.4 kPa vs. 2.2 kPa in reader 1; 2.7 kPa vs. 2.4 kPa in reader 2; <i>P </i>< 0.001). The modified LSM showed superior sensitivity (0.841 vs. 0.659 in reader 1; 0.864 vs. 0.705 in reader 2; <i>P </i>< 0.05) and area under the curve (0.901 vs. 0.820 in reader 1; 0.912 vs. 0.843 in reader 2; <i>P </i>< 0.05) for detecting advanced fibrosis (≥F3) than conventional LSM.</p><p><strong>Conclusion: </strong>The exclusion of intrahepatic segmental vessels from ROIs in MRE affected the LSM and enhanced diagnostic performance for advanced fibrosis.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the impact of excluding intrahepatic segmental vessels on liver stiffness measurement and advanced fibrosis diagnosis using magnetic resonance elastography.\",\"authors\":\"Wook Kim, Jeong Ah Hwang, Ji Hye Min, Sunyoung Lee, Ji Eun Lee, Jaeseung Shin, Woo Kyoung Jeong\",\"doi\":\"10.1177/02841851241263335\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The impact of excluding intrahepatic segmental vessels from regions of interest (ROIs) on liver stiffness measurement (LSM) via magnetic resonance elastography (MRE) remains uncertain.</p><p><strong>Purpose: </strong>To determine the effect of excluding intrahepatic segmental vessels from ROIs on LSM obtained from MRE.</p><p><strong>Material and methods: </strong>This retrospective analysis included 95 participants who underwent successful two-dimensional gradient recalled-echo MRE before hepatic tumor resection (n = 49) or living liver donation (n = 46). 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引用次数: 0
摘要
背景:目的:确定从感兴趣区(ROIs)排除肝段内血管对通过磁共振弹性成像(MRE)测量肝脏硬度(LSM)的影响:这项回顾性分析包括95名在肝肿瘤切除术(49人)或活体肝脏捐献(46人)前成功接受二维梯度回波MRE的参与者。传统的LSM是在95%置信区域内的弹性图上手动绘制ROI,在肝囊中保留1厘米,排除大的肝门血管、胆囊、肝脏病变和伪影。此外,还通过排除肝段内血管来确定修正的 LSM。通过配对样本符号秩检验对两种方法得出的 LSM 进行比较。采用 McNemar 检验和 Delong 检验计算和比较晚期肝纤维化的诊断性能。使用METAVIR系统对手术标本进行肝纤维化分期评估:结果:改良 LSM 比传统 LSM 大(读者 1 为 2.4 kPa,读者 2 为 2.2 kPa;读者 2 为 2.7 kPa,读者 2 为 2.4 kPa;P P P P 结论:在 MRE 的 ROI 中排除肝段内血管会影响 LSM 并提高晚期肝纤维化的诊断性能。
Exploring the impact of excluding intrahepatic segmental vessels on liver stiffness measurement and advanced fibrosis diagnosis using magnetic resonance elastography.
Background: The impact of excluding intrahepatic segmental vessels from regions of interest (ROIs) on liver stiffness measurement (LSM) via magnetic resonance elastography (MRE) remains uncertain.
Purpose: To determine the effect of excluding intrahepatic segmental vessels from ROIs on LSM obtained from MRE.
Material and methods: This retrospective analysis included 95 participants who underwent successful two-dimensional gradient recalled-echo MRE before hepatic tumor resection (n = 49) or living liver donation (n = 46). The conventional LSM was determined by manually drawing ROIs on the elastogram within the 95% confidence region, staying 1 cm within the liver capsule and excluding large hilar vessels, the gallbladder, hepatic lesions, and artifacts. In addition, the modified LSM was determined by excluding intrahepatic segmental vessels. LSMs obtained by the two methods were compared with paired sample signed-rank test. Diagnostic performance for advanced fibrosis was calculated and compared using McNemar's test and Delong's test. The stage of hepatic fibrosis was assessed using surgical specimens by the METAVIR system.
Results: The modified LSM was larger than the conventional LSM (2.4 kPa vs. 2.2 kPa in reader 1; 2.7 kPa vs. 2.4 kPa in reader 2; P < 0.001). The modified LSM showed superior sensitivity (0.841 vs. 0.659 in reader 1; 0.864 vs. 0.705 in reader 2; P < 0.05) and area under the curve (0.901 vs. 0.820 in reader 1; 0.912 vs. 0.843 in reader 2; P < 0.05) for detecting advanced fibrosis (≥F3) than conventional LSM.
Conclusion: The exclusion of intrahepatic segmental vessels from ROIs in MRE affected the LSM and enhanced diagnostic performance for advanced fibrosis.
期刊介绍:
Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.