刺五加中的愈创木内酯倍半萜内酯及其抗神经炎症活性

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Phytochemistry Pub Date : 2024-07-19 DOI:10.1016/j.phytochem.2024.114223

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引用次数: 0

摘要

从 Cichorium glandulosum Boiss et Huet 的气生部分分离出了 8 种未描述过的愈创木内酯倍半萜内酯 cicholosumins A-H 和 12 种已知的愈创木内酯。通过一维和二维核磁共振光谱数据、电子圆二色性、量子化学计算和单晶 X 射线衍射分析，确定了它们的结构。化合物 9α-hydroxy-3-deoxyzaluzanin C、epi-8α-angeloyloxycichoralexin、8-O-methylsenecioylaustricin 和 lactucin 具有很强的抗神经炎活性，IC50 值分别为 1.69 ± 0.11、1.08 ± 0.23、1.67 ± 0.28 和 1.82 ± 0.27 μM。机理研究表明，表-8α-angeloyloxycichoralexin通过NF-κB和MAPK途径抑制神经炎症。

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Guaianolide sesquiterpene lactones from Cichorium glandulosum and their anti-neuroinflammation activities

Eight undescribed guaianolide sesquiterpene lactones cicholosumins A-H and twelve known ones were isolated from the aerial parts of Cichorium glandulosum Boiss et Huet. Their structures were established by 1D and 2D NMR spectroscopic data, electronic circular dichroism, quantum chemical calculations and single crystal X-ray diffraction analysis. Compounds 9α-hydroxy-3-deoxyzaluzanin C, epi-8α-angeloyloxycichoralexin, 8-O-methylsenecioylaustricin and lactucin showed strong anti-neuroinflammation activity with IC₅₀ values of 1.69 ± 0.11, 1.08 ± 0.23, 1.67 ± 0.28 and 1.82 ± 0.27 μM, respectively. The mechanism research indicated that epi-8α-angeloyloxycichoralexin inhibited neuroinflammation through the NF-κB and MAPK pathways.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.