Shuman He, Xiuhua Chao, Yi Yuan, Jeffrey Skidmore, Kristin M Uhler
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Assessing Neural Synchrony in the Cochlear Nerve to Electrical Stimulation in Children With Auditory Neuropathy Spectrum Disorder.
Objectives: This study reported phase locking values (PLVs) that quantified the trial-to-trial phase coherence of electrically evoked compound action potentials in children with auditory neuropathy spectrum disorders (ANSD) and children with Gap Junction Beta 2 (GJB2) mutations, a patient population without noticeable cochlear nerve damage.
Design: PLVs were measured at three electrode locations in 11 children with ANSD and 11 children with GJB2 mutations. Smaller PLVs indicated poorer neural synchrony. A linear mixed-effects model was used to compare PLVs measured at different electrode locations between participant groups.
Results: After controlling for the stimulation level effect, children with ANSD had smaller PLVs than children with GJB2 mutations at all three electrode locations.
Conclusions: Cochlear-implanted children with ANSD show poorer peripheral neural synchrony than children with GJB2 mutations.
期刊介绍：
From the basic science of hearing and balance disorders to auditory electrophysiology to amplification and the psychological factors of hearing loss, Ear and Hearing covers all aspects of auditory and vestibular disorders. This multidisciplinary journal consolidates the various factors that contribute to identification, remediation, and audiologic and vestibular rehabilitation. It is the one journal that serves the diverse interest of all members of this professional community -- otologists, audiologists, educators, and to those involved in the design, manufacture, and distribution of amplification systems. The original articles published in the journal focus on assessment, diagnosis, and management of auditory and vestibular disorders.
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