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Improving the Predictive Strength of Better-Ear Four-Frequency Pure-Tone Average With the Addition of the Tinnitus and Hearing Survey-Hearing Subscale.
IF 2.6 2区 医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Pub Date : 2025-01-31 DOI: 10.1097/AUD.0000000000001633
Gregory M Ellis, Rebecca Bieber, Alyssa Davidson, LaGuinn Sherlock, Michele Spencer, Douglas Brungart
<p><strong>Objectives: </strong>The objective of this project was to quantify the relative efficacy of a four-frequency pure-tone average in the better ear (PTA4), the Hearing subscale of the Tinnitus and Hearing Survey (THS-H), and a combination of the two in predicting speech-in-noise performance, hearing aid recommendation, and hearing aid use among United States service members (SMs).</p><p><strong>Design: </strong>A two-analysis retrospective study was performed. The first analysis examined the degree to which better-ear PTA4 alone, THS-H alone, and better-ear PTA4 in conjunction with THS-H predicted performance on a speech-in-noise test, the modified rhyme test. Three binomial mixed-effects models were fitted using better-ear PTA4 alone, THS-H alone, and both measures as primary predictors of interest. Age and sex were included as covariates in all models. The models were compared to one another using Chi-square goodness-of-fit tests and the best-fitting model was examined. Data from 5988 SMs were analyzed in the first analysis. The second analysis examined the degree to which better-ear PTA4 alone, THS-H alone, and better-ear PTA4 in conjunction with THS-H predicted two hearing aid-related outcomes: recommendation for hearing aids by a clinician and hearing aid use. Three receiver operating characteristic curves were fit for each question for better-ear PTA4 alone, THS-H alone, and better-ear PTA4 + THS-H. The area under the curve was bootstrapped to generate confidence intervals to compare the three measures. Data from 8001 SMs were analyzed in the second analysis.</p><p><strong>Results: </strong>In the first analysis, all three models explained more variance than chance; however, the better-ear PTA4 + THS-H model was a significantly better fit than either the better-ear PTA4 alone or the THS-H alone models. Significant main effects of better-ear PTA4 and THS-H indicated that proportion correct decreased as better-ear PTA4 and THS-H increased. A significant interaction was observed such that proportion correct decreased more rapidly if both better-ear PTA4 and THS-H were increasing in tandem. In the second analysis, better-ear PTA4 + THS-H showed good predictive discrimination of a prior hearing aid recommendation. For predicting hearing aid use, better-ear PTA4 was the only predictor with an area under the curve bootstrapped confidence interval that overlapped 0.50, indicating better-ear PTA4 alone is a chance predictor for hearing aid use. Both THS-H alone and better-ear PTA4 + THS-H predicted hearing aid use better than chance, but had poor discrimination overall.</p><p><strong>Conclusions: </strong>Adding the THS-H to the better-ear PTA4 improves predictions of speech intelligibility in noise, has good predictive strength for hearing aid recommendations, and predicts hearing aid use better than chance. This study provides evidence for using surveys in conjunction with objective data when evaluating hearing ability and recommending int
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引用次数: 0
Machine-Learning Predictions of Cochlear Implant Functional Outcomes: A Systematic Review.
IF 2.6 2区 医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Pub Date : 2025-01-29 DOI: 10.1097/AUD.0000000000001638
Jonathan T Mo, Davis S Chong, Cynthia Sun, Nikita Mohapatra, Nicole T Jiam
<p><strong>Objectives: </strong>Cochlear implant (CI) user functional outcomes are challenging to predict because of the variability in individual anatomy, neural health, CI device characteristics, and linguistic and listening experience. Machine learning (ML) techniques are uniquely poised for this predictive challenge because they can analyze nonlinear interactions using large amounts of multidimensional data. The objective of this article is to systematically review the literature regarding ML models that predict functional CI outcomes, defined as sound perception and production. We analyze the potential strengths and weaknesses of various ML models, identify important features for favorable outcomes, and suggest potential future directions of ML applications for CI-related clinical and research purposes.</p><p><strong>Design: </strong>We conducted a systematic literature search with Web of Science, Scopus, MEDLINE, EMBASE, CENTRAL, and CINAHL from the date of inception through September 2024. We included studies with ML models predicting a CI functional outcome, defined as those pertaining to sound perception and production, and excluded simulation studies and those involving patients without CIs. Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we extracted participant population, CI characteristics, ML model, and performance data. Sixteen studies examining 5058 pediatric and adult CI users (range: 4 to 2489) were included from an initial 1442 publications.</p><p><strong>Results: </strong>Studies predicted heterogeneous outcome measures pertaining to sound production (5 studies), sound perception (12 studies), and language (2 studies). ML models use a variety of prediction features, including demographic, audiological, imaging, and subjective measures. Some studies highlighted predictors beyond traditional CI audiometric outcomes, such as anatomical and imaging characteristics (e.g., vestibulocochlear nerve area, brain regions unaffected by auditory deprivation), health system factors (e.g., wait time to referral), and patient-reported measures (e.g., dizziness and tinnitus questionnaires). Used ML models were tree-based, kernel-based, instance-based, probabilistic, or neural networks, with validation and test methods most commonly being k-fold cross-validation and train-test split. Various statistical measures were used to evaluate model performance, however, for studies reporting accuracy, the best-performing models for each study ranged from 71.0% to 98.83%.</p><p><strong>Conclusions: </strong>ML models demonstrate high predictive performance and illuminate factors that contribute to CI user functional outcomes. While many models showed favorable evaluation statistics, the majority were not adequately reported with regard to dataset characteristics, model creation, and validation. Furthermore, the extent of overfitting in these models is unclear and will likely result in poor generalization to new data.
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引用次数: 0
Evaluating a Hearing Loop Implementation for Live Orchestral Music.
IF 2.6 2区 医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Pub Date : 2025-01-27 DOI: 10.1097/AUD.0000000000001626
Sean McWeeny, Laurel J Trainor, Steve Armstrong, Dan Bosnyak, Hany Tawfik, Ian C Bruce

Objectives: Live music creates a sense of connectedness in older adults, which can help alleviate the social isolation frequently associated with hearing loss and aging. However, most hearing-aid (HA) users are dissatisfied with the sound quality of live music and rate sound quality as important to them. Assistive listening systems are frequently independent of a user's HAs and fall short in tailoring to each individual's hearing loss. The present study thus tested whether the use of a hearing loop would improve sound quality during an orchestral concert.

Design: Participants with symmetrical moderate-to-severe hearing loss were assigned to use Sonova-provided HAs with a telecoil (n = 20) or their own HAs (n = 8) without a telecoil during a performance by the Hamilton Philharmonic Orchestra. We changed loop input to use one of three feeds every 5 minutes: a mix of microphones from the hall's standard assistive feed on the first balcony (house condition), a mix of microphones located on the stage (stage condition), or no input to the loop (no feed). After each 5-minute interval, we collected sound quality and naturalness ratings for the previous 5 minutes.

Results: Sound quality and naturalness ratings were highly related (rRM = 0.81), though each provided unique insight. Repeated measures analysis of variance found significant differences among the loop feed conditions for sound quality and naturalness, with the no feed condition significantly outperforming the house condition on sound quality [t(18) = -3.73, adj. p = 0.005] and naturalness [t(18) = -4.15, adj. p = 0.002]. Mixed effects models allowed us to retain the richness of a repeated observation dataset and provided point estimates of the overall quality and naturalness among conditions; however, assumption violations of normality and homoskedasticity prevented further interpretation.

Conclusions: Though HA-integrated assistive listening systems are a promising option for improving live music for people with hearing loss, a hearing loop does not seem to be crucial for orchestral music. Future directions include improving lyric understanding for music with vocals and customizing user experience via Bluetooth Low Energy Audio systems.

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引用次数: 0
The Performance of the Acoustic Change Complex Versus Psychophysical Behavioral Measures: A Systematic Review of Measurements in Adults.
IF 2.6 2区 医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Pub Date : 2025-01-24 DOI: 10.1097/AUD.0000000000001634
Sarah Meehan, Marc P van der Schroeff, Marloes L Adank, Wichor M Bramer, Jantien L Vroegop

Objectives: The acoustic change complex (ACC) is a cortical auditory evoked potential that shows promise as an objective test of the neural capacity for speech and sound discrimination, particularly for difficult-to-test populations, for example, cognitively impaired adults. There is uncertainty, however, surrounding the performance of the ACC with behavioral measures. The objective of this study was to systematically review the literature, focusing on adult studies, to investigate the relationship between ACC responses and behavioral psychophysical measures.

Design: Original peer-reviewed articles conducting performance comparisons between ACCs and behavioral measures in adults were identified through systematic searches. The review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for reporting, and the methodological quality of the included articles was assessed.

Results: A total of 66 studies were retrieved that conducted adult ACC measurements, of which 27 studies included performance comparisons. Meta-analysis revealed a total of 41 significant correlations between ACC responses (amplitudes, latencies, and thresholds) and behavioral measures of speech perception (2 weak, 28 moderate, and 11 strong correlations), and 12 significant moderate/strong correlations were identified with behavioral measures of frequency discrimination.

Conclusions: This systematic review finds that ACC responses are associated with speech perception and frequency discrimination, in addition to other types of sound discrimination. The choice of evoking stimuli, ACC outcome measure, and behavioral measure used may influence the strength and visibility of potential correlations between the objective (ACC) and behavioral measures. The performance of the ACC technique highlighted in this review suggests that this tool may serve as an alternative measure of auditory discrimination when corresponding behavioral measures prove challenging or unfeasible.

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引用次数: 0
The Benefits of Hearing Aids for Adults: A Systematic Umbrella Review.
IF 2.6 2区 医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Pub Date : 2025-01-24 DOI: 10.1097/AUD.0000000000001620
Diana Tang, Yvonne Tran, Rebecca J Bennett, Charles Lo, Jien Nien Lee, Jessica Turner, Bamini Gopinath

Objectives: This umbrella review aims to summarize the major benefits of hearing aid usage in adults by synthesizing findings from published review articles.

Design: A comprehensive search of databases, including MEDLINE, EMBASE, PsycINFO, and Google Scholar, was conducted. The search was limited to English-language review articles published between 1990 and 2023, focusing on hearing aid outcomes in at least 5 adults (aged ≥18 years). Two researchers independently screened titles, abstracts, and full-text articles, and conducted a quality assessment using the Joanna Briggs Checklist for Systematic Reviews and Research Syntheses. A third researcher was involved in discussions with the 2 researchers to resolve conflicts during the screening and quality assessment stages.

Results: Eleven articles were included in this review. There were three systematic reviews with meta-analysis and eight systematic reviews without meta-analysis. The quality assessment indicated that articles scored between 6 and 11 out of a total of 11 criteria. Three articles met all quality criteria. Study participants tended to be middle-aged (≥40 years) or older adults (≥65 years). Participant gender was less clear as this was not consistently reported but appeared to favor men. This umbrella review found that speech perception, communication function, hearing handicap, and self-assessed hearing aid benefit were consistently positively associated with hearing aid use in the analysis of included studies. Hearing handicap was the most frequently reported outcome with evidence from four different studies supporting its mitigation with hearing aid use. There was insufficient evidence in terms of benefit on balance, cognitive function, depression, tinnitus, loneliness, and social isolation. There was conflicting evidence on the impact of hearing aid use on quality of life. Among eligible studies, there were no reports of negative impacts of hearing aid use.

Conclusions: There are a number of potential benefits associated with hearing aid use. However, this review found that there was a clear lack of high-quality evidence and limited use of robust study design to support the benefits of hearing aids on other outcomes such as quality of life and cognition. Inconsistent use and interpretation of various outcome measures makes it difficult to produce homogenous data which is needed to make more conclusive statements about the benefits of hearing aids.

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引用次数: 0
Wearing Hearing Protection Makes Me Worse at My Job: Impacts of Hearing Protection Use on Sensorimotor Tracking Performance.
IF 2.6 2区 医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Pub Date : 2025-01-24 DOI: 10.1097/AUD.0000000000001630
Matthew G Wisniewski, C Shane Chuwonganant

Objectives: Occupational hearing loss is a significant problem worldwide despite the fact that it can be mitigated by the wearing of hearing protection devices (HPDs). When surveyed, workers frequently report that worsened work performance while wearing HPDs is one reason why they choose not to wear them. However, there have been few studies to supplement these subjective reports with objective measures. Where they do exist, assessed performance measures have mostly characterized auditory situational awareness in gross terms (e.g., average speech comprehension scores over an entire session). The temporal dynamics of performance and HPD impacts on nonauditory aspects of work performance are largely unknown. In the present study, we aimed to fill this gap in the literature by measuring how HPD usage impacted sensorimotor tracking performance in relation to ongoing auditory events.

Design: In two experiments, listeners heard commands sourced from the coordinate response measure (CRM) corpus (i.e., sentences of the form "Ready go to now"). These commands informed listeners of which of nine moving on-screen objects to track with a computer mouse (e.g., "blue four" refers the listener to a blue square). The commands were presented in background street noise and were heard under either "No HPD" or "HPD" conditions. In experiment 1, HPD wearing was simulated with a digital filter designed to mimic the attenuation profile of a passive HPD. In experiment 2, actual HPDs were worn by listeners. Continuous recording of tracking error allowed us to simultaneously examine how HPD wearing impacted speech comprehension, the accuracy of tracking, and how tracking accuracy varied as a function of time on task and ongoing auditory events (e.g., the presentation of a critical CRM sentence).

Results: In both experiments, listeners spent less time tracking the correct object in the HPD condition. After trimming data to those time points in which the target object was known, worse performance was exhibited by the HPD condition than the No HPD condition. In the examination of the temporal dynamics of tracking error, it was apparent that differences arose strongly during the presentation of CRM sentences.

Conclusions: Workers' complaints of poorer performance while wearing HPDs are justified and extend beyond just diminished auditory situational awareness. The negative impact on nonauditory aspects of work performance may be strongest around critical listening periods. Addressing these aspects of performance will be an important part of addressing HPD nonuse in occupational settings.

{"title":"Wearing Hearing Protection Makes Me Worse at My Job: Impacts of Hearing Protection Use on Sensorimotor Tracking Performance.","authors":"Matthew G Wisniewski, C Shane Chuwonganant","doi":"10.1097/AUD.0000000000001630","DOIUrl":"https://doi.org/10.1097/AUD.0000000000001630","url":null,"abstract":"<p><strong>Objectives: </strong>Occupational hearing loss is a significant problem worldwide despite the fact that it can be mitigated by the wearing of hearing protection devices (HPDs). When surveyed, workers frequently report that worsened work performance while wearing HPDs is one reason why they choose not to wear them. However, there have been few studies to supplement these subjective reports with objective measures. Where they do exist, assessed performance measures have mostly characterized auditory situational awareness in gross terms (e.g., average speech comprehension scores over an entire session). The temporal dynamics of performance and HPD impacts on nonauditory aspects of work performance are largely unknown. In the present study, we aimed to fill this gap in the literature by measuring how HPD usage impacted sensorimotor tracking performance in relation to ongoing auditory events.</p><p><strong>Design: </strong>In two experiments, listeners heard commands sourced from the coordinate response measure (CRM) corpus (i.e., sentences of the form \"Ready <call sign> go to <color> <number> now\"). These commands informed listeners of which of nine moving on-screen objects to track with a computer mouse (e.g., \"blue four\" refers the listener to a blue square). The commands were presented in background street noise and were heard under either \"No HPD\" or \"HPD\" conditions. In experiment 1, HPD wearing was simulated with a digital filter designed to mimic the attenuation profile of a passive HPD. In experiment 2, actual HPDs were worn by listeners. Continuous recording of tracking error allowed us to simultaneously examine how HPD wearing impacted speech comprehension, the accuracy of tracking, and how tracking accuracy varied as a function of time on task and ongoing auditory events (e.g., the presentation of a critical CRM sentence).</p><p><strong>Results: </strong>In both experiments, listeners spent less time tracking the correct object in the HPD condition. After trimming data to those time points in which the target object was known, worse performance was exhibited by the HPD condition than the No HPD condition. In the examination of the temporal dynamics of tracking error, it was apparent that differences arose strongly during the presentation of CRM sentences.</p><p><strong>Conclusions: </strong>Workers' complaints of poorer performance while wearing HPDs are justified and extend beyond just diminished auditory situational awareness. The negative impact on nonauditory aspects of work performance may be strongest around critical listening periods. Addressing these aspects of performance will be an important part of addressing HPD nonuse in occupational settings.</p>","PeriodicalId":55172,"journal":{"name":"Ear and Hearing","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine Learning-Based Diagnosis of Chronic Subjective Tinnitus With Altered Cognitive Function: An Event-Related Potential Study. 基于机器学习的慢性主观性耳鸣认知功能改变诊断:一项事件相关电位研究。
IF 2.6 2区 医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Pub Date : 2025-01-20 DOI: 10.1097/AUD.0000000000001623
Jihoo Kim, Kang Hyeon Lim, Euijin Kim, Seunghu Kim, Hong Jin Kim, Ye Hwan Lee, Sungkean Kim, June Choi
<p><strong>Objectives: </strong>Due to the absence of objective diagnostic criteria, tinnitus diagnosis primarily relies on subjective assessments. However, its neuropathological features can be objectively quantified using electroencephalography (EEG). Despite the existing research, the pathophysiology of tinnitus remains unclear. The objective of this study was to gain a deeper comprehension of the neural mechanisms underlying tinnitus through the comparison of cognitive event-related potentials in patients with tinnitus and healthy controls (HCs). Furthermore, we explored the potential of EEG-derived features as biomarkers for tinnitus using machine learning techniques.</p><p><strong>Design: </strong>Forty-eight participants (24 patients with tinnitus and 24 HCs) underwent comprehensive audiological assessments and EEG recordings. We extracted N2 and P3 components of the midline electrodes using an auditory oddball paradigm, to explore the relationship between tinnitus and cognitive function. In addition, the current source density for N2- and P3-related regions of interest was computed. A linear support vector machine classifier was used to distinguish patients with tinnitus from HCs.</p><p><strong>Results: </strong>The P3 peak amplitudes were significantly diminished in patients with tinnitus at the AFz, Fz, Cz, and Pz electrodes, whereas the N2 peak latencies were significantly delayed at Cz electrode. Source analysis revealed notably reduced N2 activities in bilateral fusiform gyrus, bilateral cuneus, bilateral temporal gyrus, and bilateral insula of patients with tinnitus. Correlation analysis revealed significant associations between the Hospital Anxiety and Depression Scale-Depression scores and N2 source activities at left insula, right insula, and left inferior temporal gyrus. The best classification performance showed a validation accuracy of 85.42%, validation sensitivity of 87.50%, and validation specificity of 83.33% in distinguishing between patients with tinnitus and HCs by using a total of 18 features in both sensor- and source-level.</p><p><strong>Conclusions: </strong>This study demonstrated that patients with tinnitus exhibited significantly altered neural processing during the cognitive-related oddball paradigm, including lower P3 amplitudes, delayed N2 latency, and reduced source activities in specific brain regions in cognitive-related oddball paradigm. The correlations between N2 source activities and Hospital Anxiety and Depression Scale-Depression scores suggest a potential link between the physiological symptoms of tinnitus and their neural impact on patients with tinnitus. Such findings underscore the potential diagnostic relevance of N2- and P3-related features in tinnitus, while also highlighting the interplay between the temporal lobe and occipital lobe in tinnitus. Furthermore, the application of machine learning techniques has shown reliable results in distinguishing tinnitus patients from HCs, reinforcing the v
目的:由于缺乏客观的诊断标准,耳鸣的诊断主要依赖于主观评价。然而,其神经病理特征可以用脑电图(EEG)客观量化。尽管已有研究,但耳鸣的病理生理机制尚不清楚。本研究的目的是通过比较耳鸣患者和健康对照(hc)的认知事件相关电位,更深入地了解耳鸣的神经机制。此外,我们利用机器学习技术探索了脑电图衍生特征作为耳鸣生物标志物的潜力。设计:48名参与者(24名耳鸣患者和24名hc患者)接受了全面的听力学评估和脑电图记录。我们采用听觉奇球范式提取中线电极的N2和P3分量,探讨耳鸣与认知功能的关系。此外,计算了N2-和p3相关区域的电流源密度。使用线性支持向量机分类器将耳鸣患者与hc患者区分开来。结果:耳鸣患者在AFz、Fz、Cz和Pz电极上P3峰幅度明显降低,而在Cz电极上N2峰潜伏期明显延迟。来源分析显示,耳鸣患者双侧梭状回、双侧楔、双侧颞回和双侧脑岛的N2活性明显降低。相关分析显示医院焦虑抑郁量表抑郁评分与左脑岛、右脑岛和左颞下回N2源活动显著相关。在传感器水平和源水平上,共使用18个特征来区分耳鸣和hc患者,其最佳分类性能显示验证准确率为85.42%,验证灵敏度为87.50%,验证特异性为83.33%。结论:本研究表明,耳鸣患者在认知相关的古怪范式中表现出显著的神经加工改变,包括P3波幅降低,N2潜伏期延迟,认知相关的古怪范式中特定脑区源活动减少。N2源活动与医院焦虑抑郁量表-抑郁评分之间的相关性提示耳鸣生理症状与其对耳鸣患者的神经影响之间存在潜在联系。这些发现强调了耳鸣中N2-和p3相关特征的潜在诊断意义,同时也强调了耳鸣中颞叶和枕叶之间的相互作用。此外,机器学习技术的应用在区分耳鸣患者和hc方面显示出可靠的结果,加强了N2和P3特征作为耳鸣生物标志物的可行性。
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引用次数: 0
Sleep-Associated Traits and Hearing Difficulties in Noise: A Bidirectional Mendelian Randomization Study. 噪声环境下睡眠相关特征与听力障碍:一项双向孟德尔随机化研究。
IF 2.6 2区 医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Pub Date : 2025-01-20 DOI: 10.1097/AUD.0000000000001625
Chunyan Liu, Xiaonan Wu, Jin Li, Shan Song, Jing Guan, Qiuju Wang

Objectives: The aim of this study was to investigate the causal relationships between sleep-associated traits and hearing difficulties in noise (HDinN) by Mendelian randomization (MR) analysis.

Design: Single nucleotide polymorphisms associated with chronotype, insomnia, sleep duration, daytime dozing or sleeping, and ease of getting up in the morning were extracted from European population genome-wide association study pooled data for bidirectional MR analysis. The MR-Egger regression, the inverse variance weighted technique, and the weighted median method were used for data analysis. The study was then expanded to include South Asian, East Asian, African, and Greater Middle Eastern populations.

Results: MR analysis indicated that in European populations, ease of getting up in the morning is a protective factor for HDinN (odds ratio [OR] = 0.932, p = 4.22 × 10-5, pFDR = 5.62 × 10-4), while shorter sleep duration was a risk factor (undersleepers: OR = 1.164, p = 0.002, pFDR = 0.014). In addition, there was an indicative causal association between daytime dozing and HDinN (OR = 1.089, p = 0.046, pFDR = 0.123). The conclusions were consistent in African populations (ease of getting up: OR = 0.696, p = 0.012, pFDR = 0.041, sleep duration: OR = 0.677, p = 0.032 pFDR = 0.091, daytime dozing: OR = 1.164, p = 0.002, pFDR = 0.014). In the reverse direction, there was a significant causal association between HDinN and both chronotype (OR = 1.413, p = 0.011, pFDR = 0.042) and ease of getting up in the morning (OR = 0.668, p = 1.75 × 10-5, pFDR = 3.49 × 10-4) in European populations, with similar conclusions respectively reached in East Asian (OR = 1.085, p = 0.010, pFDR = 0.045) and African populations (OR = 0.936, p = 0.002, pFDR = 0.012). Furthermore, although not observed in European populations, exploratory studies in non-European populations suggested a potential association between insomnia and HDinN (East Asian: OR = 1.920, p = 0.011, pFDR = 0.043, African: OR = 2.080, p = 0.004, pFDR = 0.019, South Asian: OR = 1.981, p = 1.59 × 10-4, PFDR = 0.002, Greater Middle Eastern: OR = 2.394, p = 0.002, pFDR = 0.012), and vice versa (Greater Middle Eastern: OR = 1.056, p = 0.014, pFDR = 0.044).

Conclusions: This study identified a potential bidirectional causal relationship between sleep-associated traits and HDinN. However, the underlying mechanisms of the causal relationships reported here have yet to be elucidated.

目的:采用孟德尔随机化(MR)分析方法,探讨睡眠相关特征与噪音听力障碍(HDinN)之间的因果关系。设计:从欧洲人群全基因组关联研究汇总数据中提取与时间型、失眠、睡眠时间、白天打盹或睡眠以及早晨起床难易度相关的单核苷酸多态性,用于双向MR分析。采用MR-Egger回归、方差反加权法和加权中位数法进行数据分析。随后,这项研究扩大到南亚、东亚、非洲和大中东地区的人口。结果:MR分析显示,在欧洲人群中,早晨起床容易是HDinN的保护因素(比值比[OR] = 0.932, p = 4.22 × 10-5, pFDR = 5.62 × 10-4),睡眠时间较短是HDinN的危险因素(睡眠不足者:OR = 1.164, p = 0.002, pFDR = 0.014)。此外,白天打盹与HDinN之间存在指示性因果关系(OR = 1.089, p = 0.046, pFDR = 0.123)。结论在非洲人群中是一致的(容易起床:OR = 0.696, p = 0.012, pFDR = 0.041,睡眠时间:OR = 0.677, p = 0.032 pFDR = 0.091,白天打盹:OR = 1.164, p = 0.002, pFDR = 0.014)。相反,HDinN与欧洲人群的睡眠类型(OR = 1.413, p = 0.011, pFDR = 0.042)和早晨起床难易程度(OR = 0.668, p = 1.75 × 10-5, pFDR = 3.49 × 10-4)之间存在显著的因果关系,东亚人群(OR = 1.085, p = 0.010, pFDR = 0.045)和非洲人群(OR = 0.936, p = 0.002, pFDR = 0.012)也得出了类似的结论。此外,尽管不是在欧洲人口,探索性的研究在非欧洲人群指出潜在的关联失眠和HDinN(东亚:= 1.920,p = 0.011, pFDR = 0.043,非洲:= 2.080,p = 0.004, pFDR = 0.019,南亚:= 1.981,p = 1.59×身手,尤其pFDR = 0.002,大中东:= 2.394,p = 0.002, pFDR = 0.012),反之亦然(大中东:= 1.056,p = 0.014, pFDR = 0.044)。结论:本研究确定了睡眠相关特征与HDinN之间潜在的双向因果关系。然而,这里报道的因果关系的潜在机制尚未阐明。
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引用次数: 0
Benefits of Cochlear Implantation and Hearing Preservation for Children With Preoperative Functional Hearing: A Prospective Clinical Trial. 一项前瞻性临床试验:人工耳蜗植入和听力保护对术前功能性听力患儿的益处。
IF 2.6 2区 医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Pub Date : 2025-01-16 DOI: 10.1097/AUD.0000000000001636
Lisa R Park, Margaret E Richter, Erika B Gagnon, Shannon R Culbertson, Lillian W Henderson, Margaret T Dillon

Objectives: This study was designed to (1) compare preactivation and postactivation performance with a cochlear implant for children with functional preoperative low-frequency hearing, (2) compare outcomes of electric-acoustic stimulation (EAS) versus electric-only stimulation (ES) for children with versus without hearing preservation to understand the benefits of low-frequency acoustic cues, and (3) to investigate the relationship between postoperative acoustic hearing thresholds and performance.

Design: This was a prospective, 12-month between-subjects trial including 24 pediatric cochlear implant recipients with preoperative low-frequency functional hearing. Participant ages ranged from 5 to 17 years old. They were recruited at their device activation and fit with EAS or ES based on their postoperative thresholds. Group outcomes were compared for single-word recognition, masked sentence recognition, perceived hearing abilities, speech production, receptive language, expressive language, and prosodic identification.

Results: Children experienced improvements in word recognition, subjective hearing, speech production, and expressive language with EAS or ES as compared with their preoperative abilities. Children using EAS performed better on a prosodic identification task and had higher subjective hearing scores postactivation as compared with children using ES. There was a significant relationship between postoperative thresholds at 125 Hz and prosodic identification.

Conclusions: The results of this study support cochlear implantation for children with normal-to-moderate low-frequency hearing thresholds and severe-to-profound high-frequency hearing loss. They also highlight the benefits of postoperative hearing preservation for language development.

目的:本研究旨在(1)比较术前低频听力正常的儿童人工耳蜗激活前和激活后的表现;(2)比较有听力保护和无听力保护的儿童电声刺激(EAS)和纯电刺激(ES)的结果,以了解低频声提示的好处;(3)研究术后声学听力阈值与表现之间的关系。设计:这是一项前瞻性的、为期12个月的受试者间试验,包括24名术前低频功能性听力的儿童人工耳蜗受者。参与者年龄从5岁到17岁不等。他们在设备激活时被招募,并根据术后阈值与EAS或ES相匹配。比较各组结果的单字识别、掩句识别、感知听力能力、言语产生、接受性语言、表达性语言和韵律识别。结果:与术前相比,采用EAS或ES治疗的儿童在单词识别、主观听力、言语产生和表达语言方面均有改善。与使用EAS的儿童相比,使用EAS的儿童在韵律识别任务上表现更好,并且在激活后具有更高的主观听力分数。术后125 Hz阈值与韵律识别之间存在显著关系。结论:本研究结果支持对正常至中度低频听力阈值和重度至重度高频听力损失的儿童进行人工耳蜗植入。他们还强调了术后听力保护对语言发育的好处。
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引用次数: 0
The Auditory Environment at Early Intervention Groups for Young Children With Hearing Loss: Signal to Noise Ratio, Background Noise, and Reverberation. 听力损失幼儿早期干预组的听觉环境:信噪比、背景噪声和混响。
IF 2.6 2区 医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Pub Date : 2025-01-10 DOI: 10.1097/AUD.0000000000001627
Annerenée Meijer, Michel Ruben Benard, Aart Woonink, Deniz Başkent, Evelien Dirks

Objectives: One important aspect in facilitating language access for children with hearing loss (HL) is the auditory environment. An optimal auditory environment is characterized by high signal to noise ratios (SNRs), low background noise levels, and low reverberation times. In this study, the authors describe the auditory environment of early intervention groups specifically equipped for young children with HL.

Design: Seven early intervention groups for children with HL were included in the study. A total of 26 young children (22 to 46 months) visiting those groups participated. Language Environmental Analysis recorders were used to record all sounds around a child during one group visit. The recordings were analyzed to estimate SNR levels and background noise levels during the intervention groups. The unoccupied noise levels and reverberation times were measured in the unoccupied room either directly before or after the group visit.

Results: The average SNR encountered by the children in the intervention groups was +13 dB SNR. The detected speech of the attending professionals achieved the +15 dB SNR recommended by the American Speech-Language-Hearing Association in approximately 42% of the time. The unoccupied noise levels were between 29 and 39 dBA, complying with acoustic norms for classroom environments (≤35 dBA, by ANSI/ASA 12.60-2010 Part 1) for six out of seven groups. Reverberation time was between 0.3 and 0.6 sec for all groups, which complies to the acoustic norms for classroom environments for children without HL (0.6 or 0.7 sec, depending on the room size), while only one group complied to the stricter norm for children with HL (0.3 sec).

Conclusions: The current findings show characteristics of the auditory environment of a setting that is specifically equipped and designed for groups of children with HL. Maintaining favorable SNRs seems to be the largest challenge to achieve within the constraints of an environment where young children gather, play, and learn. The results underscore the importance of staying attentive to keep spoken language accessible for children with HL in a group setting.

目的:听觉环境是促进听力损失儿童语言学习的一个重要方面。最佳听觉环境的特点是高信噪比(SNRs)、低背景噪声水平和低混响时间。在这项研究中,作者描述了专门为HL幼儿配备的早期干预组的听觉环境。设计:研究包括7个儿童HL早期干预组。访问这些小组的26名幼儿(22至46个月)参加了研究。语言环境分析记录仪被用来记录在一个小组访问期间一个孩子周围的所有声音。对录音进行分析,以估计干预组期间的信噪比水平和背景噪声水平。在小组访问之前或之后,在未被占用的房间中测量了未被占用的噪音水平和混响时间。结果:干预组患儿平均信噪比为+13 dB。与会专业人员检测到的语音在大约42%的时间内达到了美国语音语言听力协会推荐的+15 dB信噪比。七组中有六组的未占用噪音水平在29至39 dBA之间,符合教室环境的声学标准(ANSI/ASA 12.60-2010 Part 1规定的≤35 dBA)。所有组的混响时间在0.3 - 0.6秒之间,符合非HL儿童教室环境的声学标准(0.6或0.7秒,具体取决于房间大小),而只有一组符合HL儿童更严格的标准(0.3秒)。结论:目前的研究结果显示了听觉环境的特点,这是专门为HL儿童群体配备和设计的。在幼儿聚集、玩耍和学习的环境中,保持良好的信噪比似乎是最大的挑战。结果强调了保持注意力的重要性,以保持口语对HL儿童在群体设置。
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引用次数: 0
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Ear and Hearing
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